延迟胃空化在患有全身性硬化症的患者中确定了一个高风险的临床亚组
Francisco A Felix-Tellez1, Alfredo Guillen- Del-Castillo2,3, Claudia Pedroza4
1Digestive System Research Unit, Department of Digestive Diseases, Vall d'Hebron University Hospital, Barcelona, Spain.
Rheumatology (Oxford, England)
|February 6, 2026
概括
胃动力障碍影响了全身性硬化症 (SSc) 患者的35%,与肺部疾病相关,并预测了与SSc相关的死亡或肺移植等不良结果.
科学领域:
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 系统性硬化症 (SSc) 是一种复杂的自身免疫性疾病.
- 胃肠道不运动是SSc的常见并发症.
- 在SSc中对胃功能的客观评估至关重要.
研究的目的:
- 为了确定客观定义的胃动力障碍在SSc患者的患病率.
- 评估胃不运动和SSc临床/免疫特征之间的关联.
- 评估胃不运动性对SSc.不良结果的预测价值.
主要方法:
- 94名SSc患者的回顾性队列研究.
- 使用标准化的4小时固体胃排空光学.
- 胃动性定义为4小时后≥20%的胃留.
主要成果:
- 胃动力障碍的患病率为35% (33/94名患者).
- 与间歇性肺病和缺少食道收缩性相关.
- 独立预测SSc相关的死亡和/或肺移植 (aHR=4.23).
结论:
- 在SSc中胃不运动呈现出明显的临床和血清学现象型.
- 对胃功能的客观评估对于SSc的风险分层很重要.
- 胃不运动是SSc.严重不良结果的独立预测因素.
相关概念视频
Gastric Emptying
3.8K
Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...
3.8K
Relative Risk
2.2K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.2K
Gastric Motility
3.2K
Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
3.2K
Gastric Phase of Digestion
3.4K
The gastric phase of digestion begins as soon as food enters the stomach. The incoming food bolus triggers neural and hormonal mechanisms, which last approximately 3 to 4 hours. During this phase, the stomach undergoes significant changes to prepare the food for further digestion and absorption.
When food enters the stomach, it stretches the stomach walls and activates stretch receptors. This triggers local reflexes of the enteric nervous system, mediated through the myenteric plexus. These...
When food enters the stomach, it stretches the stomach walls and activates stretch receptors. This triggers local reflexes of the enteric nervous system, mediated through the myenteric plexus. These...
3.4K
Factors Affecting the Risk of Infection
13.7K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.7K
Second Order systems II
411
In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
411
![Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F50301.jpg&w=3840&q=50)

