[新辅助疗法和肌肉侵入性膀癌的完整反应:可以保存尿膀吗?]
Christian Bolenz1, Friedemann Zengerling2, Hubert Kübler3
1Klinik für Urologie und Kinderurologie, Universitätsklinikum Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Deutschland. christian.bolenz@uniklinik-ulm.de.
Urologie (Heidelberg, Germany)
|February 6, 2026
概括
器官保存疗法为肌肉侵入性膀癌 (MIBC) 提供了激进囊切除术 (RC) 的替代方案. 新的方法旨在保持生活质量,同时实现与RC相似的瘤结果.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 手术瘤学手术瘤学
背景情况:
- 带有骨盆淋巴切除和尿路转移的激进囊切除术 (RC) 是肌肉侵入性膀癌 (MIBC) 的标准治疗方法.
- 虽然有效,但RC与严重的外科手术后并发症和降低生活质量有关.
- 器官保护性三模治疗是选择MIBC患者的替代方案.
研究的目的:
- 审查MIBC器官保存方法的当前发展和挑战.
- 确定成功实施膀癌器官保护的先决条件.
- 探索在MIBC治疗中维持生活质量的新概念.
主要方法:
- 这篇叙事综述综合了有关MIBC器官保存策略的现有文献.
- 它检查了系统疗法的进展及其对治疗反应的影响.
- 该审查讨论了对治疗反应评估的验证代用参数的需求.
主要成果:
- 由于改善的全身疗法和更高的响应率,对MIBC的器官保存概念的兴趣日益增加.
- 新的方法旨在维护生活质量,其瘤结果与RC相比.
- 开发和验证可靠的重新分期方法对于临床重新评估至关重要.
结论:
- 在MIBC中,通过有效的全身疗法,器官的保存越来越可行.
- 成功实施需要强大的替代参数来评估病理和系统反应.
- 为了推进器官保存策略,联合重新分期方法的进一步开发和验证至关重要.
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