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ортодонтика衍生微塑料影响巨细胞分化和恒常性

Jordan Warunek^1,2,3, Stephen Warunek⁴, Michael Calderon^5,6

¹Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, USA.

Progress in orthodontics

|February 6, 2026

概括

直接打印的正牙材料比传统材料释放的微塑料更多,巨细胞很容易吞这些微塑料. 这可能会引发炎症反应,影响口腔和全身健康.

科学领域:

生物材料科学生物材料科学
免疫学免疫学免疫学
聚合物化学聚合物化学

背景情况:

合成聚合物在牙科设备中普遍存在,例如对齐器和保持器.
关于微塑料从直接打印的光聚合物与传统的热成型聚合物释放的数据有限.
微塑料存在于人体组织中,口腔巨细胞可能与正牙颗粒相互作用.

研究的目的:

系统地描述由正牙聚合物释放的微塑料和结构.
为了可视化这些粒子被巨细胞吸收.
评估微塑料暴露对巨细胞分化的影响.

主要方法:

经过测试的直接打印 (例如,ActiveMemoryTM DCA,Tera Harz TA-28) 和热成型 (例如,InvisacrylTM,Zendura®,Invisalign®) 的聚合物.
在人工唾液中化聚合物盘,每天旋转一周.
通过流细胞计和显微镜量化颗粒的释放;评估巨细胞的吸收和分化.

主要成果:

所有测试的聚合物都释放出可检测的微型和纳米塑料.
直接打印的聚合物释放的度更高,主要是微型颗粒.
巨细胞对2-10微米塑料进行了细胞化,并且以尿为基础的直接打印材料诱导了类似M1的炎症性巨细胞表型.

结论:

常见的正牙材料释放出巨细胞吸收的微/纳米塑料.
直接打印的聚合物释放出更多的免疫刺激颗粒,可能会影响口腔和全身免疫力.
评估微塑料的释放对于医疗和牙科设备中更安全的材料选择至关重要.

关键词:

调整器设备的调整器.流动细胞计量流动细胞计量巨细胞是一个巨细胞.微塑料是一种微塑料.纳米塑料的纳米塑料

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