磁控输送囊内镜用于精确地将药物输送到肠道病变
Chen He1, Xi Jiang1, Ting Zhang1
1Department of Gastroenterology, National Clinical Research Center for Digestive Diseases, Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China.
一种新的磁控输送囊内镜 (MDCE) 系统,可在肠道病变中进行非侵入性,向性药物输送. 该系统在猪模型中显示出高可行性和有效性,为改进的局部治疗铺平了道路.
科学领域:
- 胃肠病学 胃肠病学
- 医疗器械 医疗器械
- 内镜检查是指内镜检查.
背景情况:
- 目前的非侵入性药物输送方法在针对性肠道病变方面缺乏精度.
- 准确地将局部治疗输送到特定的肠部位仍然是一个临床挑战.
研究的目的:
- 评估一种新型磁控传递囊内镜 (MDCE) 系统的可行性和有效性,用于精确,非侵入性地向肠道病变提供局部治疗.
- 评估MDCE系统的定位精度,图像质量,机动性和程序效率.
主要方法:
- 评估MDCE系统的可行性是使用ex vivo猪肠道模型与27个染色标记模拟病变进行评估.
- 在体内评估涉及四只巴马小型猪,评估实时光学可视化下对模拟小肠病变的药物输送.
- 效率指标包括准成功率,图像质量,MDCE机动性,以及伤准和染料递送的时间.
主要成果:
- 在ex vivo模型中,MDCE系统实现了超过80%的目标成功,在体内精度为91.7% (22/24病变染色).
- 图像质量和机动性被评为最佳.
- 虽然病变准时间各不相同 (16-191秒),但染料的传递在病变类型和位置上始终是快速的 (4-11秒).
结论:
- 磁控输送囊内镜 (MDCE) 系统是一种可行的和有效的工具,用于精确的,视觉引导的局部药物输送到肠道病变.
- MDCE系统提供了高精度和最佳性能特征,有可能推进非侵入性肠道疗法.
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