在原发性肝细胞癌中[68Ga]Ga-FAPI-04的放射性分布模式
Dongling Zhu1, Yuankai Zhu1, Sijuan Zou1
1Departments of Nuclear Medicine and PET.
Clinical nuclear medicine
|February 6, 2026
概括
加-68 Ga-FAPI-04正子发射断层扫描/计算机断层扫描 (PET/CT) 显示,与原发性肝细胞癌 (HCC) 瘤中心相比,其瘤边缘的吸收率更高. 这种模式突出了针对FAP向治疗的潜力,专注于瘤外围.
科学领域:
- 核医学是一种核医学.
- 在瘤学瘤学.
- 放射化学 放射化学是指辐射化学.
背景情况:
- 肝细胞癌 (HCC) 是一种具有重大全球影响的原发性肝癌.
- 纤维细胞激活蛋白 (FAP) 经常在各种癌症的瘤微环境中表达,包括HCC.
- [68Ga]Ga-FAPI-04是一种定子发射断层扫描 (PET) 追踪器,准FAP.
研究的目的:
- 研究[68Ga]Ga-FAPI-04在原发性肝细胞癌 (HCC) 中的生物分布和放射性吸收模式.
- 为了比较[68Ga]Ga-FAPI-04在HCC患者的瘤边缘和瘤中心的吸收.
主要方法:
- 一项前性试验 (ChiCTR2000039099) 包括23名原发性HCC患者,病变26个.
- 患者在一周内接受了[18F]FDG PET/CT和[68Ga]Ga-FAPI-04 PET/CT.
- 定量分析比较了瘤边缘和中部区域的痕迹剂吸收.
主要成果:
- [68Ga]Ga-FAPI-04显示,与瘤中心相比,瘤边缘的吸收显著更高 (SUVmax,P<0.001;SUV平均值,P<0.01).
- 越来越多的SUVmax门导致FAPI的利息数量集中在外围地区,并在中心地区急剧下降.
- 这表明明显的中央异质性,在HCC病变的核心中标志物吸收率较低.
结论:
- [68Ga]Ga-FAPI-04 PET/CT揭示了初级HCC.中明显的边缘吸收模式.
- 强烈的外围吸收支持用于光导向手术和治疗瘤边缘残留或复发性疾病的FAP向方法.
- [68Ga]Ga-FAPI-04的有限的中央吸收可能会对针对整个瘤体积的FAP向治疗构成挑战.
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