相关实验视频
Updated: Feb 8, 2026

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Culture of Bladder Cancer Organoids as Precision Medicine Tools
Published on: December 28, 2021
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概括
手术前的血液标记物,如专蛋白与血球蛋白比率 (AGR),可以预测膀癌患者进行激进囊切除术的结果. 低AGR与较差的无病生存率和整体生存率有关,有助于风险分层.
科学领域:
- 在瘤学瘤学.
- 生物标志物研究 生物标志物研究
- 外科手术的结果
背景情况:
- 基于血液的炎症和营养生物标志物是癌症的重要预后指标.
- 激进囊切除术 (RC) 是非转移性膀癌的主要治疗方法.
- 确定术前预测结果后RC的预测因素对于患者管理至关重要.
研究的目的:
- 在接受RC的非转移性膀癌患者中研究术前血液生物标志物和术后结果之间的关联.
- 评估白蛋白与球蛋白比率 (AGR),中性粒细胞与淋巴细胞比率 (NLR) 和C反应蛋白与白蛋白比率 (CAR) 的预后值.
主要方法:
- 对235名患有非转移性膀癌的患者进行了回顾性分析,这些患者接受了RC.
- 收集和分析了AGR,NLR和CAR的手术前数据.
- 进行了生存分析,包括多变量分析,以评估生物标志物相关性.
主要成果:
- 较低的AGR与较差的5年无病存活率 (DFS) 和整体存活率 (OS) 显著相关.
- 高的NLR与更糟糕的DFS和OS相关.
- 高的CAR显著与较差的OS相关,而低的AGR则是较差DFS和OS的独立预测因素.
结论:
- 手术前的血液生物标志物,特别是AGR,可以帮助识别非转移性膀癌的高风险患者.
- AGR 作为一种简单,具有成本效益的工具,用于风险分层和RC后的治疗规划.
- 这些发现支持在膀癌患者的预后评估中使用常规血液检查.
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