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剩余胆固醇炎症指数对心力衰竭风险的预测值:NHANES的一项横截面研究

Ji Ouyang¹, Jiayuan Song², Xingxing Zhang¹

¹College of traditional Chinese medicine, Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China.

|February 6, 2026

概括

剩余胆固醇炎症指数 (RCII) 预测了心力衰竭 (HF) 的风险. 升高的RCII水平与老年人,特别是非吸烟者中HF发病率增加有关.

科学领域:

心血管医学心血管医学
代谢综合征是代谢综合征的一种.
炎症生物标志物炎症生物标志物

背景情况:

剩余胆固醇炎症指数 (RCII) 结合了剩余胆固醇和C反应蛋白来评估代谢和炎症风险.
心力衰竭 (HF) 是一个重大的公共卫生问题,需要改进风险预测策略.

研究的目的:

调查RCII与美国人口中患心力衰竭 (HF) 的长期风险之间的关联.
确定RCII是否可以作为HF发展的独立预测因素.

主要方法:

从国家健康和营养检查调查中分析了45岁以上的6027名参与者的数据.
参与者根据自然日志转换的RCII (ln RCII) 被分为四分之一.
使用后勤回归,受限立方线曲线和接收器运行特征 (ROC) 曲线分析来评估ln RCII和HF风险之间的关联,控制共变量.

主要成果:

在 ln RCII (Q4) 的最高四分位数与年龄较大,BMI较高,糖尿病,高血压和高血压患病率增加有关.
经过校正后勤回归,Q4组的HF风险明显高于Q1组.
每个单位增加的ln RCII独立地与36%的高风险增加有关 (P < .001),通过立方线分析证实了线性关系. 在ROC分析中,AUC值为0.59 (P < .05).

结论:

升高的RCII水平独立预测中年和老年人心力衰竭发展的长期风险增加.
该RCII可以作为一个有价值的生物标志物来识别高风险的个人HF.
吸烟状态显著缓解了这种关联,在非吸烟者中观察到更强的预测有效性.

关键词:

尼汉斯 (NHANES) 是一个名人.跨截面研究是跨截面研究.心脏衰竭是因为心脏衰竭.预测价值是一个预测值.这是残留胆固醇炎症.

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