估计葡萄糖处置率和发生心脏病的变化:来自CHARLS和ELSA的前性队列研究
Jiangtao Li1,2,3, Xiang Wei1,2,3
1Division of Cardiovascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Medicine
|February 6, 2026
概括
估计葡萄糖处置率 (eGDR) 的变化会影响心脏病风险. 持续低或下降的eGDR水平显著增加患心脏病的可能性,突出了针对性干预的必要性.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 估计的葡萄糖处理率 (eGDR) 是已知的心血管疾病风险因素.
- 以前的研究还没有充分探讨eGDR纵向变化对心脏病发病率的影响.
研究的目的:
- 调查随着时间的推移对eGDR的变化与发生性心脏病的风险之间的关联.
- 在两个大型潜在队列中使用K-means集群分析eGDR轨迹.
主要方法:
- 利用了中国健康与退休纵向研究 (CHARLS) 和英国老龄纵向研究 (ELSA) 的数据.
- 通过基线和后续测量评估eGDR的变化,并通过K-means集群将其分类为不同的类别.
- 采用Cox的比例危险模型来确定发生心脏病的危险比率 (HRs) 和95%置信区间 (95%CI),调整为混因素.
主要成果:
- 在CHARLS中,与始终高的eGDR类相比,始终低 (HR 1.86) 和高下降 (HR 1.65) 的eGDR类观察到心脏病风险更高.
- 埃尔萨显示了类似的趋势,持续低 (HR 1.68) 和持续中等 (HR 1.45) 的eGDR类与心脏病风险增加有关.
- 较低的eGDR总水平在两个队列中始终与较高的心脏病发病风险有关,并观察到显著的负线性关系.
结论:
- eGDR的轨迹,特别是降低或持续低水平,与发生性心脏病风险增加有显著的关联.
- 保持高的eGDR水平和开发定制的干预措施来改善eGDR对于心血管疾病预防策略至关重要.
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