基于网络药理学和分子对接技术的Qufushengji水凝对治疗炎的作用和机制的研究
Zhe Meng1, Shuangxin Zhang, Qirui Zhang
1School of Nursing, Changchun University of Chinese Medicine, Changchun, China.
Medicine
|February 6, 2026
概括
这项研究探讨了Qufushengji水凝.
科学领域:
- 药理学和中国传统医学 (TCM) 研究.
- 计算生物学和网络药理学.
背景情况:
- 炎是静脉注射治疗的常见副作用,目前的治疗方法有局限性.
- 传统中医 (TCM) 提供了炎管理的潜在治疗途径.
研究的目的:
- 阐明Qufushengji水凝的作用机制,这是一个新的TCM局部制剂,用于治疗炎.
- 确定关键的活性成分,标和途径,涉及Qufushengji水凝对炎的治疗作用.
主要方法:
- 网络药理学和分子对接被用来选活性成分和标.
- 波茨-盖伊模型预测了皮肤透性; PPI和药物成分目标疾病网络被构建.
- 进行了基因本体学 (GO) 和KEGG通路丰富分析,以及分子对接验证.
主要成果:
- 确定了90种活性成分和221个潜在的标;21个关键标与炎相关的标相交.
- 艾比特酸,脱水艾比特酸和烯酸被确定为核心活性成分.
- 确定IL-10,TNF,IL-6,VCAM1和ICAM1是核心标,调节免疫-炎症,代谢和感染途径.
结论:
- 昆福生吉水凝通过多组分,多目标,多途径的方法来治疗炎.
- 这项研究为在炎治疗中使用TCM提供了理论基础.
- 这项研究支持Qufushengji水凝的潜力,作为一个有效的炎治疗.
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