开发装载着西斯和伏利诺斯塔特组合的尼奥索姆纳米颗粒,用于癌症治疗
Hazar Ali1,2, Zainab Lafi1,2, Naeem Shalan1,2
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan.
PloS one
|February 6, 2026
概括
这项研究开发了与西斯普拉丁和伏利诺斯塔特共同装载的阴体纳米颗粒,用于增强癌症治疗. 这种新型配方在体外证明了改善药物输送,持续释放和优越的抗癌疗效.
科学领域:
- 纳米技术在药物输送中的应用
- 癌症治疗方法 癌症治疗方法
- 配方科学科学 配方科学
背景情况:
- 西斯 (CIS) 是一种重要的化疗剂,但由于耐药性和全身毒性而面临限制.
- 结合像CIS这样的DNA损伤剂和像Vorinostat (VOR) 这样的表观遗传调节剂,为提高癌症治疗疗效提供了一个有希望的策略.
- 由于CIS和VOR的物理化学性质不同,CIS和VOR的联合交付具有挑战性.
研究的目的:
- 开发和描述与西斯普拉丁和伏利诺斯塔特 (NIO-CIS-VOR) 共同装载的阴体纳米颗粒.
- 为了评估NIO-CIS-VOR配方的物理化学特性.
- 为了评估共同载荷的体体的体外抗癌活性.
主要方法:
- 使用乙醇注射方法制备尼奥索姆,将CIS封装在水核中,VOR封装在脂质双层中.
- 描述涉及动态光散射 (DLS) 用于粒子大小,多分散率指数 (PDI) 和泽塔潜力;传输电子显微镜 (TEM) 用于形态学;和里埃变换红外光谱 (FTIR) 用于封装确认.
- 对HT-29,A549和PANC-1癌细胞系进行了封装效率 (EE%),药物释放动力学 (HPLC),细胞毒性测试 (IC50确定),卡斯巴-3/7激活,殖民地形成和伤口愈合测试.
主要成果:
- 优化的NIO-CIS-VOR纳米颗粒显示平均直径为152.7nm,PDI为0.12和zeta电位为-9.79mV,具有球形形态.
- 实现了高封装效率:89.3%的CIS和52.1%的VOR.
- 该配方在72小时内表现出持续释放,并且与免费药物相比,在测试的癌症细胞系中显著降低了IC50值,同时增强了细胞亡和减少了殖民地形成.
结论:
- 开发的共载体 (NIO-CIS-VOR) 能够有效地同时提供西斯和沃里诺斯塔特.
- 该配方在体外表现出持续的药物释放和协同作用的抗癌作用.
- NIO-CIS-VOR代表了组合癌症治疗的有前途的纳米载体,有可能克服单个药物的局限性.
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