18F-FDG PET/CT 在塞马格卢提德首次服用5天后:单次内射副作用
Elizabeth Katherine Anna Triumbari1,2, Margherita Lorusso1, Fiammetta Cirillo1
1Nuclear Medicine Unit - Medipass Ergéa Group, Fondazione Policlinico Universitario Campus Bio-Medico.
Clinical nuclear medicine
|February 6, 2026
概括
本案例研究强调了18F-FDG PET/CT扫描如何揭示GLP-1受体激动剂塞马格卢提德的多器官副作用,包括胃衰竭和损伤. 核医学医生必须识别这些成像表现.
科学领域:
- 核医学是一种核医学.
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 类似葡萄糖类-1 (GLP-1) 受体激动剂,如塞马格卢提德,广泛用于2型糖尿病和肥胖症.
- 副作用很常见,但成像上的多器官表现没有得到充分的记录.
研究的目的:
- 报告一例在18F-FDG PET/CT.上可视化的多器官Semaglutide诱导的副作用.
- 提高核医学医生对这些潜在的成像发现的认识.
主要方法:
- 一名患有转移性乳腺癌的60岁妇女接受了18F-FDG PET/CT,以评估治疗反应.
- 用临床评估和实验室测试来确认疑似副作用.
主要成果:
- 18F-FDG PET/CT显示了异常的胃保留,胆囊,结肠和吸收.
- 这些发现暗示了塞马格卢提德诱导的胃衰竭,胆囊炎,大肠炎和急性损伤.
- 症状在支持性护理和停止服用西马格卢类药物后消失.
结论:
- 这是第一个关于塞马格卢提德在18F-FDG PET/CT上可视化的多器官副作用的报告.
- 核医学医生应该了解GLP-1受体激动剂药物相关的副作用及其成像模式.
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