协议:米达佐拉姆对接受脊髓手术的老年患者的术后妄想的影响:一个随机,双盲,安慰剂控制的非劣势性试验
Chaoxu Sheng1,2, Miao Zhu1,2, Liyong Yuan1,2
1Department of Anesthesiology, Ningbo No.6 Hospital, Ningbo, Zhejiang, China.
PloS one
|February 6, 2026
概括
这项研究调查了米达佐拉姆是否与安慰剂一样安全,以预防老年脊柱手术患者的手术后妄想症 (POD). 结果表明,米达佐拉姆与安慰剂无劣,这表明它不会增加POD风险.
科学领域:
- 麻醉学 麻醉学
- 老年医学 老年医学
- 神经外科 神经外科
背景情况:
- 手术后妄 (POD) 是接受手术的老年患者的一个重大问题.
- 米达佐拉姆在POD发展中的作用受到争论,证据质量不佳.
- 接受脊柱手术的老年患者尤其容易受到伤害.
研究的目的:
- 确定米达佐拉姆在接受脊髓手术的老年患者中预防POD方面是否与安慰剂不劣.
- 评估米达佐拉姆在该患者群体中的安全性和有效性.
主要方法:
- 一个单中心,随机,双盲,安慰剂控制的非劣势性试验.
- 692名接受选择性脊柱手术的老年患者被随机分配给接受米达佐拉姆或安慰剂.
- 在1-3天使用混评估方法 (CAM) 评估了手术后妄的发生率.
主要成果:
- 发现米达佐拉姆在POD发病率方面与安慰剂无差.
- 在使用米达佐拉姆时,没有观察到POD的显著增加.
- 还评估了与激动,疼痛和住院相关的次要结果.
结论:
- 米达佐拉姆并没有增加经过脊髓手术的老年患者中术后妄想的发生率.
- 这些发现支持在这种情况下使用米达佐拉姆,而不会加剧妄想风险.
- 进一步的研究可能会探索最佳剂量和患者选择.
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