人类大脑干的概率绘制和自动细分包装了白质
Mark D Olchanyi1,2,3, David R Schreier1,2,4, Jian Li2,5
1Neuroscience Statistics Research Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139.
概括
一个新的工具,BrainStem Bundle Tool (BSBT),使用扩散MRI自动绘制脑干白质束的地图. 这项技术有助于了解神经系统疾病和昏迷恢复.
科学领域:
- 神经成像是一种神经成像.
- 神经解剖学是一个神经解剖学.
- 扩散式核磁共振成像 (MRI)
背景情况:
- 大脑干白质 (WM) 捆绑对意识和平衡至关重要.
- 它们的复杂结构使得在神经成像中绘制和细分很困难.
- 这限制了对健康和疾病中的脑干功能的理解.
研究的目的:
- 开发一个用于细分脑干WM捆绑的自动化工具.
- 调查这种工具在神经系统疾病和恢复中的有用性.
- 为了实现大脑干WM的可扩展映射.
主要方法:
- 开发了使用扩散MRI通道图的BrainStem捆绑工具 (BSBT).
- 在定制的概率纤维图上使用卷积神经网络.
- 经验证的BSBT与体内和体外人类大脑数据,包括组织学.
主要成果:
- BSBT成功地并自动分割了八个面向脑干WM捆.
- 在不同的扩散MRI采集协议中表现出稳健性.
- 在患有阿尔茨海默病,帕金森病,多发性硬化和TBI的患者中检测到脑干捆的明显变化.
- 在创伤性昏迷恢复中显示出预后效用.
结论:
- BSBT为自动脑干WM捆绑细分提供了一个强大的方法.
- 该工具有助于在各种神经疾病中研究大脑干WM.
- 在诊断和预后方面,BSBT具有临床应用的潜力.
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