运动的进化生物能量学
Canan Karakoç1,2, William R Shoemaker3, Jay T Lennon1
1Department of Biology, Indiana University, Bloomington, IN 47405.
概括
细菌分泌是一种生存策略,非常耗费能量,耗费近10^10的ATP. 这种能源投资使长期生存成为可能,使其成为长期恶劣条件的最佳选择.
科学领域:
- 微生物学 微生物学
- 生物化学 生物化学
- 进化生物学 进化生物学
背景情况:
- 复杂的特征需要大量的能量,但生物合成的自由能量往往很少.
- 细菌进化了持久性策略,如分泌,以在不利的环境中生存.
- 化是一种古老的细菌程序,当细胞能量几乎耗尽时就开始.
研究的目的:
- 在ATP中量化细菌胞的能量成本.
- 解决能源密集型运动在能源枯竭条件下发生的悖论.
- 了解新陈代谢限制如何影响胞效率和进化.
主要方法:
- 综合时间解析的基因组,转录组和蛋白质组资料.
- 全子周期 (形成和复苏) 的量化ATP成本.
- 将能源成本估计纳入机械模型.
主要成果:
- 细菌分泌需要近10^10的ATP,约占细胞总能量预算的10%.
- 大多数化的能量成本归因于翻译,膜合成和蛋白质周转.
- 运动是长期生存 (几个月或更长时间) 的最佳选择,因为它在即时成本和延迟收益之间进行了权衡.
结论:
- 分子化是细菌细胞中耗能最多的过程之一.
- 代谢的约束显著影响着化的效率.
- 在分泌过程中,即使是适度的能量负担也会影响细菌进化和特征维护.
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