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Updated: Feb 8, 2026

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打击抗病毒药物耐药性:一个多方位的战略

Jiao Zhou1,2, Ashim Nandi3, Yan Xu4

  • 1Ciechanover Institute of Precision and Regenerative Medicine, School of Medicine, Chinese University of Hong Kong, Shenzhen 518172, China.

Accounts of chemical research
|February 6, 2026
PubMed
概括

研究人员制定了一种多方策略,以对抗病毒蛋白酶耐药性,包括针对SARS-CoV-2主要蛋白酶 (Mpro) 的新型抑制剂和降解剂. 这种方法利用计算方法和人工智能来设计有效的抗病毒药物来对抗抗性突变.

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CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats is a adaptive immune system found in bacteria and archaea that protects against viral infections. This system enables prokaryotic cells to identify, remember, and neutralize foreign genetic elements, primarily bacteriophages, by storing fragments of the invader’s DNA as a genetic memory.The CRISPR immune response begins during an initial infection. Cas (CRISPR-associated) proteins play a central role in this...
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In circuit analysis, situations often arise where resistors are neither in series nor parallel configurations. To tackle such scenarios, three-terminal equivalent networks like the wye (Y) (Figure 1 (a)) or tee (T) and delta (Δ) (Figure 1 (b)) or pi (π) networks come into play. These networks offer versatile solutions and are frequently encountered in various applications, including three-phase electrical systems, electrical filters, and matching networks.
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When a solid cylinder rolls steadily on a rigid surface, the normal force applied by the surface on the cylinder is perpendicular to the tangent at the contact point. However, since no materials are entirely rigid, the surface's reaction to the cylinder involves a range of normal pressures.
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