女性偏见的脆弱性对父子早期生活压力的跨代影响
Ichiro Ishikawa1, Ken-Ichi Ohta2, Motoharu Imai1
1Department of Neuropsychiatry, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Psychoneuroendocrinology
|February 6, 2026
概括
父亲的早期生活压力 (ELS) 可以对子女跨代的神经发育产生负面影响. 这项研究发现,暴露于压力的雄性老鼠传递了更高的焦虑和社会缺陷,特别是在雌性后代中.
科学领域:
- 神经科学是一个神经科学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发展生物学 发展生物学
背景情况:
- 早期的生活逆境 (ELS) 有持久的代际影响.
- 父亲ELS对后代神经发育的表观遗传影响尚不清楚.
- 在大鼠模型ELS中,母体分离 (MS).
研究的目的:
- 调查父亲ELS对青少年老鼠后代的性别特异性跨代影响.
- 分析F2后代的行为和转录变化.
- 确定这些影响背后的神经机制.
主要方法:
- 作为ELS的模型,F1雄性大鼠接受了母体分离 (MS).
- 使用行为测试评估F2后代 (青少年大鼠).
- 在F2后代的中部前额皮质 (mPFC) 上执行RNA测序.
主要成果:
- 父亲ELS在F2后代中诱导了女性倾向的神经发育缺陷.
- 雌性后代的体重较低,焦虑程度更高,社会行为障碍更严重.
- 特定于女性的mPFC转录组签名揭示了mt-Nd3和突触通路的下调.
- 男子后代没有显著的转录基因变化.
结论:
- 父亲ELS可以导致女性偏见的跨代神经发育缺陷.
- 在mPFC中受损的线粒体功能可能会调解这些效应.
- 父亲的早期生活经历显著影响后代的神经发育以性别依赖的方式.
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