确保可靠的数字病理学:对HistoQC和PathProfiler进行比较分析,以检测前列腺全幻灯片图像中的文物
Daniele Ravanelli1, Erich Robbi2, Sara Citter3
1Medical Physics Department, S. Chiara Hospital, APSS Trento, Italy.
概括
在前列腺癌中,HistoQC和PathProfiler有效地评估整个幻灯片的图像质量,识别影响诊断的工件. 这些工具提高了准确性,并支持AI在数字病理学中的整合.
科学领域:
- 数字病理学数字病理学
- 计算病理学计算病理学
- 医疗图像分析 医学图像分析
背景情况:
- 全幻灯片图像 (WSIs) 对于高分辨率组织分析至关重要,但通常含有文物.
- 工艺品在WSIs可以阻碍人类和人工智能 (AI) 的准确解释,可能导致误诊.
- 现有的开源工具,如HistoQC和PathProfiler评估WSI质量,但它们在前列腺癌中的比较性能尚未得到很好的证实.
研究的目的:
- 为了比较评估HistoQC和PathProfiler在前列腺癌全幻灯片图像中的工件检测的性能.
- 确定两种工具在识别可用性,失焦和染色文物方面的可靠性和准确性.
- 评估这些工具在提高诊断准确度和促进数字病理学AI整合方面的潜力.
主要方法:
- 来自TCGA-PRAD数据集的240个前列腺癌WSI的评估,包括没有文物和分类的文物幻灯片.
- 使用接收器操作特征 (ROC) 分析将PathProfiler分数规范化并验证.
- 使用五倍交叉验证的各种回归模型 (SVR,XGBoost,LR,LightGBM,GP) 来得出HistoQC得分,并使用相关性和统计测试比较性能.
主要成果:
- PathProfiler展示了强大的文物检测能力,在染色 (0.960),失焦 (0.948) 和可用性 (0.921) 文物中具有高曲线下面面积 (AUC) 值.
- 基因质量控制,特别是SVR和LightGBM模型,与PathProfiler (ρ = 0.790-0.537,p < 0.001) 和可比的AUC (0.826-0.858) 有显著的相关性.
- 无论是HistoQC还是PathProfiler,都有效地区分了所有艺术品类别的清洁和含有艺术品的幻灯片 (p <0.05).
结论:
- 在前列腺癌诊断中,HistoQC和PathProfiler是评估WSI质量的可靠工具.
- "PathProfiler"提供了适合临床环境的高效文物检测.
- HistoQC提供了一种灵活的,基于机器学习的图像质量评估方法,补充了PathProfiler并增强了诊断工作流.
更多相关视频
05:33Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System
Published on: July 11, 2025
1.1K
07:46Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells
Published on: October 13, 2023
1.8K
相关概念视频
Reliability and Validity
14.1K
Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways.
14.1K
Comparing the Survival Analysis of Two or More Groups
607
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
607
Design Example: Designing Water Slide
630
When designing a water slide, controlling the speed of water flow is crucial for rider safety while maintaining an exciting experience. As water flows down the slide, gravity causes it to accelerate, with its speed at the bottom depending on the height from which it starts. The higher the slide, the more potential energy the water has at the top, which is converted into kinetic energy as it descends, increasing its speed.
Bernoulli's principle determines the water's velocity along the slide....
Bernoulli's principle determines the water's velocity along the slide....
630
Distribution Reliability and Automation
519
Distribution reliability in electrical power systems is critical for ensuring an uninterrupted power supply to consumers at minimal cost. According to IEEE Standard Terms, reliability is the probability that a device will function without failure over a specified time period or amount of usage. For electric power distribution, this translates to maintaining continuous power supply and addressing customer concerns over power outages. Several indices, as defined by IEEE Standard 1366-2012, are...
519
Comparing Copy Number Variations and SNPs
18.8K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
18.8K
Comparative Excretory Systems
26.7K
Animals have evolved different strategies for excretion, the removal of waste from the body. Most waste must be dissolved in water to be excreted, so an animal’s excretory strategy directly affects its water balance.
26.7K
