聚乙烯和聚乙烯酸盐微塑料的危险潜力:长期暴露后的细胞毒性和 (II) 载体作用
Puretat Saetan1, Pornwipa Phuangbubpha1, Nirawit Kaewnok2
1Environmental Assessment Research Unit, Department of Biology, Faculty of Science, Silpakorn University, Nakhon Pathom, 73000, Thailand.
The Science of the total environment
|February 6, 2026
概括
像PBS这样的可生物降解塑料可以充当"特洛伊木马",吸附和运输等重金属,尽管具有生物降解性,但仍存在环境风险. 聚烯微塑料显示出更高的细胞毒性和ROS产量.
科学领域:
- 环境科学 环境科学
- 材料科学 材料科学 材料科学
- 毒理学 毒理学 毒理学
背景情况:
- 微塑料 (MPs),如聚乙烯 (PS) 和聚乙烯 (PBS) 是普遍存在的环境污染物.
- 虽然PBS被认为是生物降解的,但其整体环境影响和潜在风险尚未完全理解.
- 评估MP与生物系统的相互作用及其携带污染物的潜力至关重要.
研究的目的:
- 为了评估PS-MPs和PBS-MPs的细胞毒性.
- 为了确定这些微塑料的 (HgCl2) 吸附和释放能力.
- 研究微塑料和吸附对人类肠道细胞的联合作用.
主要方法:
- 利用HT-29人类肠上皮细胞进行细胞毒性和积累研究.
- 细胞暴露于原始PS-MPs和PBS-MPs (~16μm) 在短期 (7天) 和长期 (28天) 期间.
- 量化了MPs的吸附/释放,并评估了细胞反应,包括生命力,活性氧物种 (ROS),亡和基因毒性.
主要成果:
- 无论是PS-MP还是PBS-MP都积聚在肠道粘液层中.
- 普里斯廷PS-MPs显著降低了细胞活力,增加了ROS和亡,而PBS-MPs显示出最小的细胞毒性.
- 与PS-MP相比,PBS-MP吸附3至7倍的,并更快地释放;带有的PBS (PBS-Hg) 降低了细胞活力,并导致染色质凝结.
结论:
- 提高PBS生物降解性的特性也可能增加其吸附和运输重金属的能力,作为"特洛伊木马".
- 可生物降解塑料本质上并不是更安全,需要对聚合物毒性和污染物载体潜力进行评估.
- 这项研究强调了与甚至可生物降解的微塑料相关的复杂环境风险,强调需要全面的安全评估.
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