相关实验视频
Updated: Feb 8, 2026

08:11
Quantitative Analysis of Chromatin Proteomes in Disease
Published on: December 28, 2012
13.7K
定量蛋白质组学分析,以确定耐火性良性偏激性定位的生物标志物
Liang Xia1, Kexin Song1, Lili Xiao1
1Department of Otolaryngology-Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Brazilian journal of otorhinolaryngology
|February 6, 2026
概括
这项研究确定了五种潜在的血清蛋白生物标志物,用于耐火性良性性发性位置 (BPPV). 这些发现可能有助于诊断BPPV并了解其分子机制.
科学领域:
- 蛋白质组学是指蛋白质组学.
- 生物化学 生物化学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 良性发性位置性 (BPPV) 导致暂时的和阴影.
- 耐火性BPPV需要对新型诊断标记物进行调查.
- 了解BPPV病原体对于有效治疗至关重要.
研究的目的:
- 为了研究在耐火性BPPV患者中的差异性血清蛋白质表达.
- 为了确定BPPV的潜在诊断生物标志物.
- 探索BPPV背后的分子机制.
主要方法:
- 使用双重质量标签 (TMT) 标签的定量蛋白质组学.
- 分析了来自30名耐性BPPV患者和30名对照患者的血清样本.
- 生物信息学分析包括集群,GO,KEGG和PPI网络.
主要成果:
- 确定了769种蛋白质,其中57种以不同的表达方式表达 (15种上调,42种下调).
- 确认了五种候选生物标记物:阿波利波蛋白A-I,A-II,C-III,纤维素玛链和果糖二酸盐阿尔多酶B.
- 这些蛋白质在耐火性BPPV患者中显示出显著的变化.
结论:
- 这是第一个基于TMT的BPPV生物标志物的定量蛋白质学研究.
- 鉴定的蛋白质为BPPV提供了潜在的诊断价值.
- 不同的蛋白质可以阐明BPPV病原体和分子机制.
相关概念视频
Quantitative Analysis
1.5K
Quantitative analysis is a technique for measuring the amount of specific constituents in a sample. When the sample's composition is unknown, qualitative analysis is performed first to identify its components, which ensures that the correct substances are measured during the quantitative phase.
In quantitative analysis, two key measurements are made: the sample quantity and a property proportional to the amount of the analyte (the substance being analyzed). This forms the basis of the...
In quantitative analysis, two key measurements are made: the sample quantity and a property proportional to the amount of the analyte (the substance being analyzed). This forms the basis of the...
1.5K
Design Example: Identifying the Locations of Monuments in the Field Using Global Positioning System Device
410
Surveyors use Global Positioning System (GPS) technology to measure the precise location and elevation of points on Earth. In a recent survey, GPS receivers were used to determine the coordinates and elevations of two park monuments. The process involved careful mission planning, data collection, and correction to ensure accuracy. The survey began with mission planning to identify optimal satellite visibility and minimize Position Dilution of Precision (PDOP). A geodetic control point...
410
Proteomics
9.8K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
9.8K
Position-effect Variegation
7.1K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
7.1K
Position and Displacement
26.4K
The position of an object defines its location relative to a convenient frame of reference at any particular time. A frame of reference is an arbitrary set of axes from which the position and motion of an object are described. Earth is often used as a frame of reference, and we often describe the position of an object as it relates to stationary objects on Earth. For example, a rocket launch could be described in terms of the position of the rocket with respect to Earth as a whole. On the other...
26.4K
Serial Position Effect
553
The serial position effect is a cognitive phenomenon where individuals are more likely to recall the first and last items in a list compared to those in the middle. This effect is divided into the primacy effect and the recency effect. The primacy effect is observed when the initial items in a list are remembered better. This occurs because these items are rehearsed more frequently or receive more elaborative processing, allowing them to be encoded into long-term memory more effectively. For...
553

