基他胺辅助心理治疗精神障碍:历史概述和系统审查
J K E Veraart1, N Schimmers2, J J Breeksema2
1University of Groningen, University Medical Center Groningen, Department of Psychiatry, Hanzeplein 1, 9713, GZ, Groningen, the Netherlands; PsyQ Haaglanden, Parnassia Psychiatric Institute, Mangostraat 1, 2552, KS, The Hague, the Netherlands.
Clinical psychology review
|February 6, 2026
概括
基他胺辅助心理治疗 (KAP) 对各种心理健康状况有希望,改善参与度和减轻症状. 然而,需要更严格的试验来确认心理治疗与胺一起带来的额外好处.
科学领域:
- 精神病学和药理学 精神病学和药理学
- 临床心理学 临床心理学
- 基于证据的医学基于证据的医学.
背景情况:
- 基胺辅助心理治疗 (KAP) 结合了药物治疗和精神疾病心理治疗.
- 关于最佳KAP方法和机制的现有证据是有限的.
研究的目的:
- 系统地审查结合胺和心理治疗的研究,直到2025年.
- 在KAP中使用的心理治疗方法进行分类.
- 综合有关KAP有效性和机制的证据.
主要方法:
- 在2025年之前发表的64篇文章 (72项研究) 的系统审查.
- 心理治疗范式的分类 (精神分析,行为,认知行为等). ) 的情况.
- 分析研究设计,包括11个随机对照试验 (RCT).
主要成果:
- 卡普证明了对抑郁症,PTSD,强迫症,SUD和饮食障碍的跨诊断有效性.
- 与单独心理治疗相比,KAP增强了治疗参与度,症状减少和反应持续时间.
- 在有限的RCT中,在胺治疗的背景下,从心理治疗中没有发现显著的附加益处或协同作用.
结论:
- 卡普在所有精神病学适应症中显示出积极的临床效应.
- 需要高质量的受控试验来评估添加剂/协同效应.
- 需要进一步的研究来建立最佳的KAP协议.
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