环境普洛素引发妊娠流产:通过TRIM21介导的MFF降解引发衰老驱动的流产

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Yi Sun 孙义¹, Yanbing Lin 林晏冰¹, Shuaishuai Xing 幸帅帅¹

¹Research Centre for Environment and Female Reproductive Health, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, China.

EBioMedicine

|February 6, 2026

概括

普洛克萨 (CIP) 抗生素暴露与无法解释的流产有关. 通过降解线粒体裂变因子 (MFF),CIP导致胎盘衰老,影响生殖健康.

科学领域:

生殖生物学生殖生物学
环境健康环境健康
细胞衰老细胞衰老

背景情况:

抗生素耐药性是全球卫生危机.
在人类中经常检测到西普洛素 (CIP),但其与不明原因流产 (UM) 的联系是未知的.
细胞衰老在UM中的作用需要进一步调查.

研究的目的:

调查环境中Ciprofloxacin暴露与无法解释的流产之间的关联.
为了阐明基因机制的Ciprofloxacin诱导的胎盘衰老和流产.
探索TRIM21和MFF在西普罗夫洛克萨引起的生殖并发症中的作用.

主要方法:

一个涉及UM病例和对照的病例控制研究.
在实验室使用小鼠模型和人类热囊细胞 (HTR-8/SVneo) 的功能测试.
对细胞衰老,线粒体功能障碍和TRIM21介导的MFF无处不在的分析.

主要成果:

尿液CIP水平升高与小组织衰老和流产相关.
在小鼠中,CIP暴露诱导了胎盘衰老和流产.
CIP上调TRIM21,促进MFF降解,导致线粒体功能障碍,衰老和流产.

结论:

这项研究确定了普洛克萨暴露作为流产的新风险因素.
这些发现揭示了涉及TRIM21,MFF和CIP诱导流产中的衰老的致病途径.
这项研究提供了潜在的治疗点,并突出了抗生素,细胞机制和生殖健康之间的相互作用.

关键词:

暴露于抗生素西普罗夫洛克萨辛的暴露.线粒体功能障碍线粒体功能障碍 TRIM21-MFF的介导性无处不在降解降解.热囊细胞细胞衰老的发生.没有解释的流产.

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