玉米粉和β-cyclodextrin纳米载体用于 Centella asiatica 聚的封装:合成,物理化学性质和pH响应的输送
Soubhagya Tripathy1, Prem Prakash Srivastav1
1Department of Agricultural and Food Engineering, Indian Institute of Technology Kharagpur, 721302, India.
Food chemistry
|February 6, 2026
概括
一种新型的玉米粉 (MS) 和β-cyclodextrin (β-CD) 纳米载体系统增强了Centella asiatica叶多 (CALE) 的口服输送. 这种响应pH的系统为功能性食品提供了更好的稳定性和有针对性的肠道释放.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 食品科学 食品科学 食品科学
背景情况:
- 亚洲叶多 (CALE) 具有治疗效益,但容易降解.
- 需要口服传递系统来保护CALE并提高其生物可用性.
- 基于多糖的纳米载体为稳定和输送生物活性化合物提供了一个有希望的方法.
研究的目的:
- 开发一种使用玉米粉 (MS) 和β-环极素 (β-CD) 的新型双多糖纳米载体系统.
- 使用MS/β-CD系统研究Centella asiatica叶多 (CALE) 的pH响应性口服输送.
- 评估CALE在纳米载体中的稳定性,封装效率和释放动力学.
主要方法:
- 制造MS/β-CD复合纳米粒子通过协同凝网络捕获和纳入复杂化.
- 纳米粒子大小,形态,封装效率和载荷能力的表征.
- 用光谱和热分析来确认纳米复合材料的结构和稳定性.
- 在模拟胃肠道条件下的pH响应释放行为的体外评估.
主要成果:
- 2:1的MS/β-CD配方产生了均的纳米粒子 (167nm),具有高封装效率 (84.8%) 和负载能力 (16.3%).
- 这些纳米复合材料表现出对热,光,离子强度和储存降解的增强稳定性.
- 这些纳米颗粒表明pH响应释放,抑制胃条件下的释放,并使目标肠道释放成为可能.
- 释放动力学遵循零顺序和科尔斯迈耶-佩帕斯模型,表明持续的多提供.
结论:
- 该MS/β-CD纳米混合系统是一个有效的,食品级平台,用于响应pH的多的口服输送.
- 这种清洁标签系统增强了多的稳定性,生物可访问性和治疗性能.
- 开发的纳米载体为功能性食品和营养药品提供了可扩展的解决方案.
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