高度卵巢癌的生态负责任和合理的间隔脱皮手术:一项观察性,雄心勃勃的队列研究
Sarah Hodent1, Naoual Bakrin2, Pascal Rousset3
1Hospices Civils de Lyon, Hôpital Lyon Sud, service de pathologie multi-sites, site sud, Oullins, Pierre-Bénite, France.
Gynecologic oncology
|February 6, 2026
概括
实施间隔除手术 (IDS) 的环保协议,大大减少了样本处理,降低了环境影响和成本. 这种方法保持了晚期卵巢癌治疗的组织病理学质量.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
- 医疗保健中的环境可持续性
背景情况:
- 对于先进的高度管卵巢癌的间隔解体手术 (IDS) 在外科病理学部门产生了相当大的工作负担.
- 评估生态负责任协议的影响对于管理大量标本至关重要.
研究的目的:
- 评估生态负责任协议 (ECO-IDS) 对IDS样品管理的影响.
- 确定协议对环境足迹,成本和报告时间的影响,而不影响诊断质量.
主要方法:
- 在ECO-IDS协议中规定了样本提交和采样策略,以进行粗略检查.
- 对20名患者的前性 (后ECO-IDS) 和后性 (前ECO-IDS) 队列进行了比较.
- 关键指标包括样品体积,碳足迹,成本,病理学报告周转时间和化疗响应得分 (CRS). 用下一代测序 (NGS) 来评估分子可行性.
主要成果:
- 在ECO-IDS小组中,每位患者发送的瓶子 (4对14) 和准备的石块 (12.5对38) 的数量显著减少 (p < 0.0001).
- 碳足迹 (8.6比24.1千克CO2eq) 和财务成本 (25.5比57.9欧元) 显著减少 (p < 0.0001).
- 病理报告验证时间减少 (7.5 vs 10天,p = 0.0131) 没有影响CRS;NGS在95%的瘤中证实TP53变体.
结论:
- 通过ECO-IDS协议,有效地减少了环境影响,财务成本和报告时间.
- 该协议确保了IDS接受的晚期卵巢癌患者组织病理学结果的质量和安全性.
- 这种生态负责任的方法对于手术病理学部门管理IDS标本来说是可行的和有益的.
更多相关视频
14:05Behavioral Assessment of Hearing in 2 to 4 Year-old Children: A Two-interval, Observer-based Procedure Using Conditioned Play-based Responses
Published on: January 23, 2017
29.7K
08:17Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells
Published on: December 9, 2016
11.3K
相关概念视频
Observational Studies
11.1K
Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
11.1K
Prediction Intervals
3.4K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
3.4K
Rationalizing Substitutions
62
Integrals involving non-rational functions are often difficult to evaluate using standard techniques, especially when radicals appear in the integrand. Rationalizing substitution provides a systematic method for simplifying such integrals by converting them into rational forms that are easier to handle.Consider a rod whose linear mass density depends on a constant linear density, a characteristic length, and the distance from the left end of the rod. Determining the total mass requires...
62
Rational Expressions
407
Rational expressions are algebraic fractions in which both the numerator and the denominator are polynomials. These expressions follow the arithmetic rules of numerical fractions but require extra care due to the presence of variables. A fundamental part of working with rational expressions is identifying values that make the expression undefined, typically those that result in division by zero or undefined radicals.Determining the DomainThe domain of a rational expression includes all real...
407
Asymptotes in Rational Functions
259
A rational function is defined as the quotient of two polynomials: where Q(x)≠0, These functions often exhibit asymptotes, which are the lines that the graph approaches but never touches. These asymptotes are classified based on how the function behaves near specific values of the input.Vertical asymptotes occur where the denominator is zero, and the numerator is not, causing the function to be undefined. These are found by solving Q(x)=0. For example: has a vertical...
259
Graded Potential
7.1K
Graded potentials are localized fluctuations in the cell membrane's electrical charge, commonly found in the dendrites of neurons. The magnitude of these potential changes depends on the strength of the initiating stimulus. In a membrane at its resting potential, a graded potential signifies a voltage shift either above -70 mV or below -70 mV.
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
7.1K
