人体皮肤内的和铜与年龄相关的再分配
Nishat Zakaria1, Alexander Griffiths2, Clarisse Ganier3
1Department of Nutritional Sciences, Faculty of Life Sciences & Medicine, King's College London, UK.
概括
基本金属和铜在老化皮肤中改变分布. 老年皮肤表现出和铜水平的改变,特别是在毛囊和汗腺中,影响皮肤健康.
科学领域:
- 皮肤病学和微量元素分析
- 研究基本金属在皮肤生理学和老化中的作用.
背景情况:
- 皮肤依赖和铜进行细胞生长,分化和亡.
- 衰老与低度炎症 (炎症) 和缺乏症的风险增加有关.
- 关于人类皮肤中和铜的空间分布以及随着年龄的增长而发生的变化,数据有限.
研究的目的:
- 为了确定人体皮肤中和铜的空间分布.
- 了解这些金属在特定皮肤细胞层和结构中的功能.
- 为了研究皮肤内的金属分布的年龄相关变化.
主要方法:
- 采用激光除感应合等离子体质谱法 (LA-ICP-MS) 进行金属测绘.
- 在不同年龄组的高加索女性捐献者的面部和腹部皮肤中分析了 (66Zn) 和铜 (63Cu).
- 实现了高空间分辨率 (5-8微米),并采用了一种新的方法进行半定量比较,使用凝微滴标准.
主要成果:
- 与皮肤相比,面部皮肤表皮层中的度 (3-5倍) 较高.
- 在面部皮肤的表皮和皮肤层中,铜的含量相对均.
- 年长的捐赠者在更深层的皮肤中表现出的增加,铜的增加,铜与的比例的改变,以及与年龄相关的铜丰富在毛囊和汗腺中.
结论:
- 该研究提出了一种创新的质谱金属成像方法来分析皮肤.
- 揭示了人类皮肤中和铜的年龄依赖的再分配的新见解.
- 研究结果表明,有可能开发基于金属的生物标志物来增强皮肤健康并对抗皮肤衰老.
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