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相关概念视频

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Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond.
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The periodic table arranges atoms based on increasing atomic number so that elements with the same chemical properties recur periodically. When their electron configurations are added to the table, a periodic recurrence of similar electron configurations in the outer shells of these elements is observed. Because they are in the outer shells of an atom, valence electrons play the most important role in chemical reactions. The outer electrons have the highest energy of the electrons in an atom...
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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
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循环生物元素及其与认知障碍的关联

Masroor Anwar1, Javed A Qadri2, Mohd Suhail Ashar1

  • 1Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
|February 6, 2026
PubMed
概括

环境污染增加了印度认知障碍 (CI) 患者的生物元素水平. 包括 (Li) 和 (Al) 在内的八种元素在CI个体中显著升高,这表明与神经毒性和早期疾病检测的潜在联系.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.生物元素是生物元素.认知障碍 认知障碍是一种认知障碍.在ICP-MS中,使用的是ICP-MS.神经退行发生神经退行.神经毒性 神经毒性

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科学领域:

  • 环境科学和毒理学
  • 神经科学和神经病学 神经科学和神经病学
  • 分析化学 分析化学

背景情况:

  • 印度快速的工业化和城市化导致生物元素的环境污染增加.
  • 血液中生物元素度的不平衡会破坏平衡,并导致神经退行性影响.
  • 生物元素与认知衰退之间的关联存在有限的数据.

研究的目的:

  • 在认知障碍 (CI) 患者中进行循环生物元素的定量分析.
  • 研究特定生物元素度与认知障碍之间的关联.

主要方法:

  • 在65名参与者中量化了19个元素,使用了感应合等离子体质谱法 (ICP-MS).
  • 进行了全面的临床和功能评估,以评估认知能力.
  • 在CI患者和对照组之间比较生物元素水平.

主要成果:

  • 与对照组相比,CI患者观察到八种元素 (Li,Al,V,Mn,Co,Ni,Zn,Ag) 的显著增加.
  • 认知障碍患者的迷你精神状态检查 (MMSE) 评分 (13.77 ± 0.99) 比对照组 (27.78 ± 0.36) 低得多.
  • 在CI患者中量化了Li,Al,V,Mn,Co,Ni,Zn和Ag的高度.

结论:

  • 研究的生物元素 (Li,Al,V,Mn,Co,Ni,Zn,Ag) 可能会在CI患者中形成独特的特征.
  • 在老年人中检测这些生物元素标志可能有助于早期管理元素诱导的神经毒性.
  • 这项研究突出了早期识别和干预认知衰退的潜在生物标志物.