一个使用Poria cocos多糖化物进行增强抗瘤免疫光疗的辅助剂代码传递纳米系统
Linxuan Shi1, Shuo Wang2, Chengzhu Song3
1State Key Laboratory of Southern Medicine Utilization, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Yunnan Province, Kunming 650500, China; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and KLMDASR of Tianjin, Nankai University, Tongyan Road, Haihe Education Park, Tianjin 300350, China.
Colloids and surfaces. B, Biointerfaces
|February 6, 2026
概括
来自Poria cocos (PPS) 的多糖化合物与光疗相结合,显示增强了抗癌免疫疗法. 这种新的方法激活免疫细胞,为治疗癌症提供了一个有希望的策略.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 免疫治疗是一种免疫疗法.
背景情况:
- 光疗,包括光动力疗法 (PDT) 和光热疗法 (PTT),在癌症治疗中显示出潜力,但往往需要加强最佳免疫疗法.
- 众所周知,多糖能刺激免疫反应,但它们在光疗基础的癌症免疫治疗中作为辅助剂的作用尚未得到充分研究.
研究的目的:
- 调查来自Poria cocos (PPS) 的多糖的潜力,作为增强光疗的抗癌免疫疗法的辅助剂.
- 开发和评估一种新的纳米系统 (PPS-ICG@PLGA NPs) 用于联合光疗和免疫疗法.
主要方法:
- 合成了装有 Poria cocos 聚糖体 (PPS) 和氨酸绿色 (ICG) 的 PLGA 纳米粒子 (PPS-ICG@PLGA NPs).
- 这些纳米颗粒的特点是它们能够在瘤部位积聚并诱导免疫细胞死亡 (ICD) 和免疫调节效应的能力.
- 在体内研究评估了抗瘤疗效,免疫细胞激活 (CD4 +,CD8 + T细胞,DCs,Tregs) 和近红外 (NIR) 激光照射下的治疗结果.
主要成果:
- PPS-ICG@PLGA NPs表现出增强的ICD和免疫调节活性.
- 纳米粒子在24小时内积聚在瘤部位,并在NIR照射后诱导了协同光热/光动力疗法 (PTT/PDT) 效应.
- 在体内给药显著增加了CD4+和CD8+T细胞比率,促进了树突细胞 (DC) 成熟,并减少了瘤中的调节性T细胞 (Treg) 透,从而导致有效的瘤抑制.
结论:
- 的可可糖多糖 (PPS) 可以显著提高光疗的免疫疗法疗效.
- 开发的PPS-ICG@PLGA纳米粒子系统是光免疫疗法的有希望的平台,证明了强大的抗癌免疫反应.
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