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D-dimer报告和协调:美国病理学家学院D-dimer能力测试计划分析
Eric Salazar1, Kristi Smock2, Taryn Cazzolli1
1Pathology and Laboratory Medicine, UT Health San Antonio, San Antonio, United States.
Seminars in thrombosis and hemostasis
|February 6, 2026
概括
D-二分体测试显示,单位在熟练测试中报告了显著的差异,这可能会影响临床准确性. 协调结果揭示了常见的偏差,突出了对标准化D-二次元报告实践的需要.
科学领域:
- 临床化学 临床化学
- 血液学 血液学 血液学
- 实验室医学 实验室医学
背景情况:
- D-二聚体对于诊断血栓性和纤维溶解性疾病至关重要.
- 在D-二聚合物测试中的挑战包括测试变异性和非标准化报告.
- 美国病理学家学院 (CAP) 血液静止和血栓形成委员会 (HaTC) 调查了D-二次体报告.
研究的目的:
- 通过2020-2023.23年的能力测试数据分析D-二次体报告实践.
- 量化报告可能不正确的D-二次元单位的实验室比例.
- 为了确定不同仪器/试剂组合的D-二次元单元报告的趋势.
主要方法:
- 分析来自多个实验室的D-二分体能力测试数据.
- 所有D-二次元的协调结果为ng/mL纤维原体等效单位 (FEU).
- 评估每种仪器/试剂组合的不同入口种群,以确定报告偏差.
主要成果:
- 实验室经常报告D-二次元单位不同于测量包装插件.
- 来自相同的仪器/试剂组合的数据围绕不同的介质聚集在一起,表明报告或转换问题.
- 用mg/L或ug/mL的DDU输入往往显示出与主要人群的显著偏差.
结论:
- 熟练测试揭示了D-二次元单元报告的潜在问题.
- 差异表明实验室实践中单位标准化或转换存在问题.
- 需要进一步的研究来确定这些报告问题是否会影响临床D-二次体解释.
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