催化剂增塑剂二甲基甲酸 (DEHP) 暴露增加了败血症死亡风险:机器学习涉及单细胞驱动的免疫失调
Jun-Jie Gao1, Li-Zhu Huang2, Tao Wang3
1Department of Clinical Laboratory, the Second Affiliated Hospital of Wannan Medical College, Wuhu 241001, China.
Toxicology and applied pharmacology
|February 6, 2026
概括
在ICU患者中,高暴露于二-2-乙基甲酸盐 (DEHP) 与增加的败血症死亡率有关. 这种免疫毒性可塑剂可能会通过MAPK14途径影响败血症的结果,这表明DEHP是一种可修改的风险因素.
科学领域:
- 关键护理医学 关键护理医学
- 毒理学 毒理学 毒理学
- 遗传学 是一个遗传学.
背景情况:
- 败血症是一个重大的全球卫生挑战,特别影响了ICU患者.
- 重症监护室 (ICU) 的患者经常接触到二二乙基甲酸盐 (DEHP),这是一种来自PVC医疗器械的免疫毒性增塑剂.
- 暴露于DEHP和败血症结局之间的因果关系尚未得到充分证实.
研究的目的:
- 研究在ICU患者中DEHP暴露和败血症结局之间的关联.
- 阐明将DEHP暴露与败血症死亡率联系起来的分子机制.
- 为了确定DEHP和败血症易感性之间的潜在因果关系.
主要方法:
- 90名ICU败血症患者和50名对照者的前性队列研究.
- 使用LC-MS/MS.量化尿中DEHP代谢物.
- 将转录组数据与预测的DEHP目标,机器学习,分子对接和孟德尔随机化分析集成.
主要成果:
- 败血症患者表现出明显更高的DEHP代谢物水平.
- 高DEHP暴露与28天生存率降低 (35%对55%) 独立相关.
- MAPK14被确定为DEHP分子通路中的关键基因,并且基因预测MAPK14表达增加了败血症易感性.
结论:
- 较高的阳性DEHP暴露与败血症死亡率的增加有关,可能由MAPK14介导.
- 暴露于DEHP是重症监护中的可修改风险因素.
- 对医疗器械的无DEHP替代品进行评估是有必要的.
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