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植物乳杆菌 (Lactobacillus Plantarum) 的益生菌可以减轻炎症,但会损害免疫力

Shanshan Yang¹, Qiuxia Cao², Kexin Yan²

¹Key Laboratory of Veterinary Biological Engineering and Technology, Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China; Jiangsu Key Laboratory for Food Quality and Safety-State, Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Ministry of Agriculture, Nanjing, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, PR China.

Microbial pathogenesis

|February 6, 2026

概括

乳酸菌植物菌的益生菌通过调节免疫细胞来减少猪的炎症. 这项研究揭示了它们的抗炎作用和对T细胞,B细胞和树突细胞的影响,为治疗应用提供了洞察力.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
胃肠病学胃肠病学

背景情况:

炎症是对刺激的关键反应,但过度的炎症会导致损伤.
植物乳杆菌 (Lactobacillus plantarum) 在养猪中被用于其抗炎性质.
与活体细菌相比,益生菌提供了增强的益生菌效应.

研究的目的:

为了研究 Lactobacillus plantarum 益生菌的抗炎作用.
分析这些益生菌对猪免疫细胞群的影响.
了解乳酸菌植物体的抗炎作用背后的机制.

主要方法:

使用了体外细胞模型和体外猪试验.
脂多糖 (LPS) 引起的炎症.
流细胞计分析了周围血液单核细胞 (PBMC) 和皮耶斑块 (PPs) 中的免疫细胞群.

主要成果:

口服的Lactobacillus plantarum益生菌抑制了LPS诱导的炎症,取决于剂量.
没有观察到肠道损伤.
炎症增加了T细胞比例,在解决后减少.
在炎症和恢复期间,B细胞和树突细胞被抑制.
自然杀手 (NK) 细胞不受炎症的影响,但在恢复期间减少.

结论:

乳酸菌植物菌的益生菌有效地缓解了猪的炎症和临床症状.
这些益生菌调节T细胞,B细胞和树突细胞种群.
这项研究为Lactobacillus plantarum 益生菌的免疫调节机制提供了新的见解.

关键词:

乳酸菌植物植物 (Lactobacillus plantarum) 是一种植物菌.免疫力是一种免疫力.这是一种炎症炎症炎症炎症.猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪益生菌益生菌益生菌

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