母亲的果糖消费差异地编程了雄性和雌性小鼠后代的过敏呼吸道反应
Amanda Santos Cavalcante1, Rodrigo Rodrigues E Lacerda1, Carolina Vieira Campos1
1Department of Pharmacology, School of Medical Sciences, State University of Campinas, Campinas, Brazil.
The Journal of nutritional biochemistry
|February 6, 2026
概括
怀孕和哺乳期间母亲的果糖消费会加剧男性后代的过敏呼吸道疾病,而女性后代则表现出不同的免疫反应. 这项研究揭示了母亲的饮食和后代过敏风险之间的因果关系.
科学领域:
- 免疫学 免疫学 免疫学
- 发展生物学 发展生物学
- 营养科学 营养科学
背景情况:
- 流行病学研究表明,母亲的糖摄入量与后代的亚托皮性呼吸道疾病之间存在联系.
- 了解母乳果糖消费对后代过敏反应的直接影响至关重要.
研究的目的:
- 研究孕妇在怀孕和哺乳期暴露于果糖对后代过敏呼吸道疾病的影响.
- 要确定这些影响是否与性别有关.
主要方法:
- 开发了一种实验性小鼠模型,将母亲暴露在液态果糖中.
- 用卵胺 (OVA) 引起过敏呼吸道疾病的敏感化和挑战.
- 对支气管支气管洗液 (BAL) 液体,血清和肺组织进行免疫细胞,细胞因子和结构变化的分析.
主要成果:
- 暴露于母乳果糖的男性后代在BAL中表现出恶化的乙氨基酸和淋巴细胞透,增加IL-10,肺副细胞乙氨基酸,原沉积和杯状细胞增生.
- 在OVA挑战后,雌性后代在BAL中表现出更高的IL-4,IL-5,TGF-β1,以及在血清中增加的IgE.
- 母亲的果糖消费导致了对后代过敏反应的性别特异编程.
结论:
- 母亲的果糖消费因果关系影响后代过敏呼吸道疾病的发展.
- 观察到的过敏反应的变化是性别特异的,男性表现出更严重的疾病特征,女性表现出明显的免疫标志物升高.
- 这项研究强调了母亲饮食在塑造后代免疫健康和过敏易感性方面的关键作用.
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