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Updated: Feb 8, 2026

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
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Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Published on: January 22, 2011

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PARG前沿:PAR营业额的机制和精密瘤学的机会

Giuliana Catara1, Gaetano Gerace2, Raffaella Lauro2

  • 1Institute of Biochemistry and Cell Biology, National Research Council of Italy, Naples 80131, Italy.

Biochemical pharmacology
|February 6, 2026
PubMed
概括

通过增加复制应激,聚ADP-核糖酶 (PARG) 抑制会放大癌细胞的死亡. 向PARG提供了一种新策略,用于克服癌症治疗中对现有的PARP抑制剂 (PARPis) 的耐药性.

关键词:
在ADP-ribosylation过程中.癌症 癌症 癌症 癌症造成的DNA损伤是DNA损伤.复制DNA复制DNA复制DNA复制在巴黎的公园里在PARP中,PARP是PARP.

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