糖尿病前期的远距离对称性多神经病变与腹部肥胖和胰岛素抵抗有关
Georgia Anastasiou1, Nikolaos Papanas2, Fotios Barkas3
1Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Diabetes research and clinical practice
|February 6, 2026
概括
远距离对称性多神经病变 (DSPN) 影响近17%的糖尿病前期患者,与中心肥胖和胰岛素抵抗有关. 早期检测和管理对于预防并发症至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 心脏病学 心脏病学
背景情况:
- 前糖尿病是一个日益严重的公共卫生问题,增加心血管疾病和2型糖尿病的风险.
- 远距离对称性多神经病变 (DSPN) 是糖尿病的常见并发症,但其患病率和糖尿病前期的危险因素不太清楚.
研究的目的:
- 为了确定成年糖尿病前期患者中DSPN的患病率.
- 调查DSPN与心脏代谢风险因素,胰岛素耐药性和动脉硬性之间的关联.
主要方法:
- 从门诊诊所对160名糖尿病前期成年人的横截面分析.
- 通过神经病症症状评分 (NSS),神经病症残疾评分 (NDS) 和振动感知值 (VPT) 诊断的DSPN.
- 动脉硬度通过带 - 关节脉冲波速率 (PWV) 进行评估.
主要成果:
- 在16.9%的参与者中诊断出DSPN.
- 独立的DSPN预测因素包括腰围和HOMA-IR (胰岛素抵抗).
- 在DSPN患者中观察到较高的PWV和异常PWV患病率,这表明动脉硬性增加.
结论:
- 在糖尿病前期,DSPN的患病率是显著的.
- 糖尿病前期的DSPN与中心肥胖和胰岛素抵抗独立相关.
- 这些发现强调了对糖尿病前期患者进行DSPN查的重要性,特别是那些患有中心肥胖症和胰岛素抵抗症的人.
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