反应性星球细胞和网络功能连接,是精神分裂症认知症状的基础:一项PET和fMRI研究
Sunah Choi1, Minah Kim2, Sang Soo Cho3
1Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea; Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.
中间轨道前皮层中的反应性星球细胞与精神分裂症的认知障碍有关. 这一发现表明精神分裂症患者认知缺陷的潜在机制.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 认知症状是精神分裂症的核心特征,其潜在机制尚不清楚.
- 假设前额皮层的改变和网络功能障碍会导致这些症状.
- 反应性星球细胞越来越多地与认知功能和精神分裂症病理生理学有关.
研究的目的:
- 研究与精神分裂症患者的认知症状相关的不连接网络中的活体反应性天体细胞信号.
- 探索星球细胞活动和认知缺陷之间的关系.
主要方法:
- 在32名精神分裂症患者和32名对照组中使用了[18F]THK5351正子发射断层扫描 (PET) 和静止状态功能性MRI.
- 使用PET测量了单胺氧化酶B (MAO-B) 作为反应性星球细胞的标记物.
- 进行了网络分析,以识别脱节的子网络,并检查了这些区域内的天体细胞信号.
主要成果:
- 精神分裂症患者表现出语言学习和记忆障碍.
- 在特定的前额头和带带状网络中,减少连接性预测了认知缺陷.
- 增加的THK5351吸收,表明更高的反应性星球细胞活动,在患者的左中枢轨道前皮层 (mOFC) 中观察到.
结论:
- 发现了在精神分裂症中脱节网络的关键区域中反应性天体细胞活性升高的证据.
- 表明mOFC反应性星体细胞与精神分裂症认知障碍的病理生理学之间存在潜在联系.
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