5×5加速与传统的重复性跨脑磁性刺激 (rTMS) 对治疗耐药抑郁症的有效性
Michael R Apostol1, Thomas E Valles2, Juliana Corlier2
1Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at University of California, 757 Westwood Plaza #4, Los Angeles, CA, 90095, USA.
Journal of affective disorders
|February 6, 2026
概括
加快的重复性跨脑磁性刺激 (rTMS) 显示出对重大抑郁症 (MDD) 的治疗有前途. 5x5协议可能与标准治疗一样有效,但在随访期间可能会出现好处.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 重复横磁刺激 (rTMS) 是FDA批准的重大抑郁症治疗方法.
- 目前的方案涉及多次每日的会议,但最佳的会议数量和脉冲计数的有效性仍然不清楚.
研究的目的:
- 为了比较加速的5x5rTMS协议 (延长间歇的Theta爆发刺激[piTBS]或共振频率[RF]刺激) 与MDD的标准每日一次rTMS的疗效.
- 为了确定加速rTMS协议是否能达到与传统治疗相比的结果.
主要方法:
- 对接受加速5x5rTMS (piTBS或RF) 的40名患者和接受标准每日一次rTMS的135名患者的临床数据的回顾性分析.
- 混合效应线性模型被用来比较群体之间的抑郁症状变化 (PHQ-9分数).
主要成果:
- 加速5x5和标准rTMS协议都有效地减少了MDD症状.
- 在治疗结束时,在加速5x5和标准方案之间没有观察到抑郁症症状变化的统计学上显著差异.
- 虽然一些患者在5x5rTMS中立即获得好处,但其他患者在随访期间出现了延迟的改善.
结论:
- 对于许多MDD患者来说,加速5x5rTMS可能是标准每日一次rTMS的可行替代方案.
- 未来的随机临床试验有必要进一步研究加速rTMS协议.
- 长期的后续评估对于准确评估加速rTMS治疗的疗效至关重要.
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