皮克林高内相乳液通过大豆蛋白分离物/pectin复合物稳定,用于nobiletin封装和体外吸收
Hong Li1, Yubo Cao1, Haizhao Song1
1College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing, 210023, China.
International journal of biological macromolecules
|February 6, 2026
概括
豆蛋白分离物/pectin (SPI/PE) 复合物形成稳定的皮克林高内部相乳液 (HIPEs),以改善消息的传递. 这些HIPE增强了功能性食品和制药应用中的nobiletin稳定性和生物可用性.
科学领域:
- 食品科学与技术 食品科学与技术
- 生物材料工程 生物材料工程
- 营养药物开发 营养药物开发
背景情况:
- 诺比丁是一种类黄类化合物,具有健康益处,但其水溶性差,生物可用性低.
- 需要有效的传递系统来克服nobiletin在实际应用中的物理化学限制.
研究的目的:
- 开发和优化大豆蛋白分离/pectin (SPI/PE) 复合稳定皮克林高内部相乳液 (HIPEs) 以提高消息传递.
- 评估SPI/PE HIPE封装中的nobiletin的物理化学稳定性,保护作用和生物可用性.
主要方法:
- 通过调整SPI/PE度和pH,准备和优化SPI/PE复合稳定皮克林HIPEs.
- 在各种环境压力 (紫外线,储存,热) 下评估乳液稳定性.
- 在体外消化,Caco-2细胞吸收研究,以及运输研究来评估nobiletin生物可访问性和生物可用性.
主要成果:
- 优化的SPI/PE复合物形成了稳定的HIPEs,具有强大的界面层,增强了乳液稳定性.
- 封装的nobiletin显著改善了对紫外线降解的抗性,延长了储存稳定性和优越的热稳定性.
- SPI/PE HIPEs显著提高了nobiletin在体外的生物可访问性,Caco-2细胞的细胞吸收和整体生物可用性,这表明了潜在的活性传输机制.
结论:
- SPI/PE复合物有效地稳定皮克林高高质量物质,为疏水化合物输送提供了强大的系统.
- 与传统方法相比,开发的HIPEs显著提高了nobiletin的稳定性和生物可用性.
- 这一战略为增强功能性食品和药品中诺比和其他疏水化合物的输送提供了一个有前途的方法.
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