相关实验视频
Updated: Feb 8, 2026
10:42
A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
Published on: February 27, 2019
9.9K
基于迷酸的鼻喷雾配方:纳米乳液与固体脂质纳米颗粒的比较研究
Maria Gioia Fabiano1, Francesca Romana Stacchini1, Giulia Tonelli2
1Department of Drug Chemistry and Technology, Sapienza University of Rome, Rome, Italy.
International journal of pharmaceutics
|February 6, 2026
概括
固体脂质纳米颗粒 (SLN) 有效地将罗斯马林酸 (RA) 内用于过敏性鼻炎. 这种纳米载体提高了RA的溶解性和保留性,为上呼吸道炎症提供了一个有前途的治疗策略.
科学领域:
- 制药科学 制药科学
- 纳米技术纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 罗斯马林酸 (RA) 具有治疗潜力,但由于溶解性差和快速清除,在临床使用中面临限制.
- 鼻腔内注射的RA受到其物理化学不稳定性和在鼻腔粘膜中的短暂停留时间的阻碍.
研究的目的:
- 开发和描述纳米载体,特别是固体脂质纳米颗粒 (SLN) 和油在水中纳米乳液 (O/W NEs),以改善红酸 (RA) 的鼻腔输送.
- 提高RA的溶解性,稳定性和粘粘性,以有效治疗过敏性鼻炎.
主要方法:
- 用RA装载的SLN和酸盐涂层的O/W NEs的设计和制备.
- 物理化学特征包括尺寸,泽塔潜力,稳定性,原子力显微镜 (AFM) 和小角度X射线散射 (SAXS).
- 评估粘膜粘合,适合用于鼻喷雾配方,以及生物活性 (抗氧化剂,抗炎).
主要成果:
- 无论是SLN还是NE,都保护RA免受降解,并提供持续释放.
- 素涂层的NE表现出增强的粘膜粘合,增加了鼻保留.
- 基于SLN的鼻喷雾显示出有利的物理化学和粘粘性,保持RA的生物活性,并减少像HMGB1.1这样的炎症标志物.
结论:
- 固体脂质纳米颗粒 (SLN) 是一个有前途的载体,用于非侵入性鼻内输送罗斯马林酸 (RA).
- 基于SLN的鼻喷雾配方为治疗过敏性鼻炎和其他上呼吸道炎症状况提供了有效的策略.
相关概念视频
02:24Comparative Excretory Systems
26.7K
Animals have evolved different strategies for excretion, the removal of waste from the body. Most waste must be dissolved in water to be excreted, so an animal’s excretory strategy directly affects its water balance.
26.7K
02:33Lewis Acids and Bases
48.4K
In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
48.4K
02:54Ions as Acids and Bases
26.6K
Salts with Acidic Ions
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
26.6K
01:38What are Lipids?
220.7K
Overview
220.7K
03:26Acids, Bases and Neutralization Reactions
63.9K
An acid-base reaction is one in which a hydrogen ion, H+, is transferred from one chemical species to another. Such reactions are of central importance to numerous natural and technological processes, ranging from the chemical transformations within cells or lakes and oceans to the industrial-scale production of fertilizers, pharmaceuticals, and other substances essential to the society.
63.9K
02:58Bronsted-Lowry Acids and Bases
105.6K
The acid-base reaction class has been studied for quite some time. In 1680, Robert Boyle reported traits of acid solutions that included their ability to dissolve many substances, to change the colors of certain natural dyes, and to lose these traits after coming in contact with alkali (base) solutions. In the eighteenth century, it was recognized that acids have a sour taste, react with limestone to liberate a gaseous substance (now known to be CO2), and interact with alkalis to form neutral...
105.6K