癌症治疗中的与疾病相关的中性粒细胞异质性:对精密免疫疗法的影响
Dezhi Sui1, Fei Liu1, Linlin Zheng1
1Institute of Molecular Medicine, School of Medicine, Liaodong University, Linjiang Campus: No. 116 Linjiang Back Street, Zhen'an District, Dandong City, Liaoning Province, China.
Critical reviews in oncology/hematology
|February 6, 2026
概括
中性粒细胞的功能随着健康和疾病而显著变化,影响癌症治疗. 了解肥胖或糖尿病等疾病中的这些变化对于开发针对中性粒细胞的有效抗瘤策略至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 中性粒细胞表现出异质性和可塑性,影响健康和疾病.
- 伴随性疾病使中性粒细胞功能复杂化,对瘤研究和抗癌药物疗效构成挑战.
- 现有的研究往往忽视了中性粒细胞功能在健康和疾病状态之间如何不同.
研究的目的:
- 审查影响中性粒细胞功能和瘤治疗疗效的条件.
- 探索炎症,衰老,肥胖,糖尿病,血栓形成和肝损伤如何改变中性粒细胞在瘤免疫中的作用.
- 讨论针对中性粒细胞的抗瘤策略.
主要方法:
- 对六种影响中性粒细胞功能和瘤治疗的疾病的文献综述.
- 对中性粒细胞表型和功能在各种疾病状态下如何变化的分析.
- 讨论针对中性粒细胞的四种抗瘤策略.
主要成果:
- 六种疾病 (炎症,衰老,肥胖,糖尿病,血栓,肝损伤) 显著改变中性粒细胞功能和抗瘤治疗结果.
- 在这些条件下,中性粒细胞的变化可能会影响瘤免疫力和治疗疗效.
- 向中性粒细胞为新型抗癌疗法提供了潜力.
结论:
- 通过向或利用伴随性疾病的患者中性粒细胞来定制癌症治疗是一个重要的考虑因素.
- 了解中性粒细胞在疾病中的可塑性是改善抗瘤药物结果的关键.
- 以中性粒细胞为中心的治疗策略显示出增强癌症治疗疗效的前景.
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