在哺乳期的奶牛中,热囊细胞分化和胚胎发育的延迟相比于无卵性母牛,乳牛的分化和胚胎发育延迟
F P J da-Silva-Junior1, I M R Leao2, M S El Azzi3
1Department of Animal Sciences, The Ohio State University, Columbus, OH; Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Journal of dairy science
|February 6, 2026
概括
均等性会影响荷尔斯坦牛的早期胚胎发育. 与原生和多生母牛相比,无卵母母牛表现出较早的热囊细胞分化和与怀孕相关的葡萄糖蛋白 (PAG) 分泌.
科学领域:
- 生殖生物学 生殖生物学
- 动物科学动物科学
- 胚胎学 胚胎学
背景情况:
- 平等性,即以前怀孕的数量,可以影响牛的生殖结果.
- 了解平衡在早期胚胎发育和胎盘中的作用对于改善生育能力至关重要.
研究的目的:
- 为了研究对等性 (无双,原双,多双) 对霍尔斯坦牛早期胚胎发育和胎盘的影响.
- 评估干扰素刺激基因 (ISG15,MX2) 和循环妊娠相关糖蛋白 (PAG) 的表达与平价相关.
主要方法:
- 在定时人工授精后,霍尔斯坦牛被按平价分组.
- 在不同的时间点收集了宫上皮细胞和血液样本,以测量mRNA丰度 (ISG15,MX2) 和PAG度.
- 荷尔蒙分析包括孕激素 (P4) 水平.
主要成果:
- 在第17天和第18天,ISG15 mRNA的丰度在原生和多生母牛中高于无生母牛.
- 循环PAG度较早增加于无双雌牛 (18.9日),而不是原双雌牛 (20日) 和多双雌牛 (20日).
- 在孕期早期,无卵性母牛表现出更高的PAG度和更高的孕激素 (P4) 水平,与早期的PAG增加相关.
结论:
- 均等性显著影响荷尔斯坦牛的早期胚胎发育和胎盘.
- 无卵性母牛表现出加速的热囊细胞分化和更早地获得PAG分泌能力.
- 这些发现突出了平等性作为影响乳牛早期怀孕建立的关键因素.
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