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Updated: Feb 8, 2026

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乳牛临床或亚临床子宫内膜炎的子宫内膜的转录图景
Lei Xie1, Muhammad Hussnain Rashid2, Qiang Dong3
1Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium.
Journal of dairy science
|February 6, 2026
概括
乳牛的亚临床 (SCE) 和临床子宫内膜炎 (CE) 涉及不同的炎症途径. CE显示了经典的传染性反应,而SCE则表明炎症失调和解决能力受损,需要量身定制的治疗.
科学领域:
- 乳牛的生殖免疫学和病理学.
- 子宫炎症的转录学和生物信息学.
- 产后疾病中的宿主微生物群相互作用.
背景情况:
- 亚临床子宫内膜炎 (SCE) 和临床子宫内膜炎 (CE) 是乳牛常见的产后生殖疾病.
- 这两种情况都与炎症失调和子宫微生物组的改变有关.
- 了解宿主的分子反应对于区分和管理这些不同的条件至关重要.
研究的目的:
- 为了确定健康,SCE和CE产后奶牛之间的子宫内膜转录基因格局的差异.
- 阐明每个条件所涉及的特定宿主反应途径.
- 为制定有针对性的预防和治疗策略提供见解.
主要方法:
- 从24只被归类为健康,SCE或CE的多雌性荷尔斯坦奶牛中采集了子宫内膜样本.
- 在子宫内膜组织上进行RNA测序,以确定差异表达基因 (DEG).
- 进行了途径丰富分析,以确定与健康对照组相比,SCE和CE中改变的生物途径.
主要成果:
- 在所有组之间观察到DEG的显著差异 (健康与SCE:250 DEG;健康与CE:1,291 DEG;SCE与CE:829 DEG).
- SCE显示TNF,IL-17,NOD类受体信号传递和细胞因子-细胞因子受体相互作用通路的调高,与FoxO信号传递的调低.
- 在CE中,免疫信号通路 (IL-17,TNF,TLRs,NF-κB) 呈上调,代谢和调节通路 (PI3K-AKT,MAPK,Wnt,PPAR) 呈下调.
结论:
- CE和SCE涉及不同的宿主反应机制,CE反映了典型的感染反应,SCE表明受调失调的炎症.
- 转录组数据突出显示CE的免疫信号发生变化和SCE的代谢/调节途径中断.
- 这些发现支持了定制策略的必要性:对SCE进行免疫调节,对CE进行细菌失生症/组织损伤向.
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