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微生物群对结直肠癌复发的影响
Nicholas R Suss1, Bidisha Barat1, Mohsen Rouhani Ravari1
1Department of Surgery, Section of Colon and Rectal Surgery, University of Chicago, Chicago, IL.
概括
肠道微生物组影响手术后结直肠癌复发. 了解和操纵这些微生物可能会改善患者的治疗结果,并降低癌症复发率.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 结肠直肠腺癌切除是标准的治疗方法,但高达30%的患者会出现复发.
- 大肠直肠癌的术后复发与患者的不良结果,高发病率和死亡率有关.
- 人们越来越认识到肠道微生物群对人类健康和疾病的影响.
研究的目的:
- 审查有关肠道微生物组在结直肠癌术后复发中的作用的当前文献.
- 探索微生物和手术诱导的微环境对瘤复发有所贡献的机制.
- 讨论潜在的基于微生物组的策略,以改善瘤的结果.
主要方法:
- 对调查肠道微生物组和结直肠癌复发的研究进行文献综述.
- 对涉及微生物在瘤发生和术后结果中的作用的研究进行批判性分析.
- 检查癌症治疗中微生物组操纵的证据.
主要成果:
- 肠道微生物组可以驱动晚期癌症阶段.
- 手术程序可以改变肠道微环境,促进致瘤细菌和代谢物.
- 特定的微生物成分和代谢物与术后复发风险的增加有关.
结论:
- 肠道微生物组是结直肠癌术后复发的一个重要因素.
- 微生物失生症和手术诱导的变化创造了一个亲瘤原生环境.
- 准肠道微生物组为改善结直肠癌治疗疗效和患者存活率提供了一个有希望的途径.
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