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Updated: Feb 8, 2026

Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor
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GPR39通过胆汁酸介导的分子信号传递

Yanyun Huang1, Zhentao Zi2, Chenliang Xia2

  • 1Department of Pharmacology School of Basic Medical Sciences and Center for AI Therapeutics, Fudan University Shanghai Medical College, Shanghai 200032, China,; School of Basic Medical Sciences, Capital Medical University, Chinese Institutes for Medical Research (CIMR), Beijing 100069, China.

The Journal of biological chemistry
|February 6, 2026
PubMed
概括

胆酸 (BAs),特别是3-O-硫酸的形式,如LCAS,TLCAS和GLCAS,激活GPR39受体. 这一发现揭示了胆酸在细胞通信中的新信号通路.

关键词:
胆汁酸 胆汁酸 胆汁酸细胞外信号调节激酶 (ERK) 的作用.G 蛋白结合受体的受体在 GPR39 中,GPR39 已经成为 GPR39 的标准.信号传输 信号传输

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