猪肠道冠状病毒的细胞进入机制
Yiping Wang1, Fei Zhao2, Qin Zhao3
1Department of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China; Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology of Ministry of Education, Sichuan Agricultural University, Chengdu 611130, China; Key Laboratory of Agricultural Bioinformatics of Ministry of Education, Sichuan Agricultural University, Chengdu 611130, China.
猪肠道冠状病毒导致猪业的重大损失. 这篇评论详细介绍了它们的细胞进入机制,重点关注尖端糖蛋白,受体和宿主因素,以告知抗病毒策略.
科学领域:
- 兽医病毒学 兽医病毒学
- 分子生物学分子生物学
- 传染性疾病 传染性疾病
背景情况:
- 像TGEV,PEDV,SADS-CoV和PDCoV这样的猪肠道冠状病毒 (PEC) 在猪中引起严重的疾病和经济损失.
- 这些病毒存在跨物种传播的风险和公共卫生威胁,因为它们能够感染多种细胞系.
研究的目的:
- 审查和总结最近关于主要猪肠道冠状病毒细胞进入机制的发现.
- 确定参与PEC进入的关键病毒和宿主因素,包括尖端糖蛋白,受体和辅因子.
- 突出潜在的抗病毒点和PEC进入途径的知识差距.
主要方法:
- 关于猪肠道冠状病毒细胞进入的最新科学发现的文献综述.
- 对详细介绍病毒尖峰葡萄糖蛋白,宿主受体,核心受体和辅因子的研究进行分析.
- 综合关于TGEV,PEDV,SADS-CoV和PDCoV.入境途径的信息.
主要成果:
- 猪肠道冠状病毒利用尖端糖蛋白与宿主细胞受体,核心受体和病毒进入的辅因子相互作用.
- 不同的PEC采用不同的宿主因素和特定的进入途径,影响它们的宿主范围和传染性.
- 了解这些相互作用对于识别广谱抗病毒开发的保存目标至关重要.
结论:
- 对PEC进入机制的全面理解对于开发有效的抗病毒疗法至关重要.
- 针对病毒进入途径是一个有希望的战略,以减轻与这些猪病毒相关的经济损失和公共卫生风险.
- 需要对特定宿主病毒相互作用进行进一步的研究,以发现新的治疗点.
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