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Updated: Feb 8, 2026

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
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细胞背景影响激酶抑制剂的选择性

Matthew J Binder1, Frances M Bashore1, Kaitlin K Dunn Hoffman2

  • 1Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

Journal of medicinal chemistry
|February 6, 2026
PubMed
概括

使用NanoBRET测定来评估细胞中酶抑制剂的选择性,揭示了通过无细胞方法错过的关键的在-和离-目标相互作用,影响了化学探针的开发.

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