补充剂对患有慢性病的成年人的影响:随机对照试验的系统审查和元分析
Natalie L X Tan1, Maya Young2, Kelly Lambert1
1School of Medical, Indigenous and Health Sciences, University of Wollongong, New South Wales, Wollongong, Australia.
Nutrition reviews
|February 6, 2026
概括
在慢性病 (CKD) 患者中补充可显著增加体重,血清,HDL-C和白. 需要进一步的高质量研究来证实对CKD管理的这些好处.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养科学 营养科学
- 临床研究 临床研究
背景情况:
- 慢性病 (CKD) 患者中缺乏症很常见,影响他们的健康.
- 之前的审查集中在血液透析患者和有限的生化标志物上.
- 这项研究将范围扩大到所有CKD成年人和不同的结果.
研究的目的:
- 系统评估补充剂对患有CKD的成年人所有结局的影响.
- 包括置换疗法和全面的临床结果范围.
主要方法:
- 在多个数据库 (Cochrane,MEDLINE,CINAHL,PubMed,Scopus,Google Scholar) 中进行了系统的搜索.
- 确定并评估了涉及慢性病成年人的随机对照试验 (RCT).
- 数据提取,偏差风险和证据质量 (GRADE) 是三位作者独立进行的.
主要成果:
- 确定了41项研究;23项被纳入了元分析,报告了176个结果.
- 补充剂显著增加了体重,血清,HDL-C,白蛋白和饮食能量摄入量.
- 没有观察到BMI,总胆固醇,甘油三,肌素或饮食中的蛋白质/摄入量的显著变化.
结论:
- 在CKD患者中补充与改善体重,血清,HDL-C,白蛋白和能量摄入有关.
- 证据的整体质量很低,表明需要更严格的研究.
- 结果表明潜在的益处,但临床应用需要进一步验证.
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