在败血症中,肠道微生物组和短链脂肪酸代谢物
Mark D Adame1, Kathleen A Stringer2, Robert P Dickson3
1Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA.
Clinics in chest medicine
|February 6, 2026
概括
败血症破坏了肠道微生物群,改变了对器官健康至关重要的短链脂肪酸 (SCFA). 恢复SCFA生产和管理其运输为败血症提供了有前途的治疗途径.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 败血症显著改变了肠道微生物组及其代谢物.
- 将这些肠道变化与器官损伤联系在一起的机制尚未完全理解.
研究的目的:
- 审查短链脂肪酸 (SCFA) 在败血症病理生理学的作用.
- 探索SCFA的生产,贩运,以及在败血症中的器官特异性影响.
主要方法:
- 文献综述侧重于SCFA在败血症的背景下.
- 关于SCFA代谢和功能的实验和人类数据的综合.
主要成果:
- 败血症消耗了SCFA产生细菌,并改变了肠道代谢.
- 败血症中泄漏和毛孔通路的增加可能导致微生物产品转移.
- 个别的SCFA (丁酸盐,酸盐,乙酸盐) 具有明显的器官特异性作用.
结论:
- 在肠道败血症轴上,SCFA是关键的调解者.
- 准SCFA及其贩运途径为败血症提供了潜在的治疗策略.
相关概念视频
Overview of Fatty Acid Metabolism
37.0K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
37.0K
Electron Transport Chains
112.6K
The final stage of cellular respiration is oxidative phosphorylation that consists of two steps: the electron transport chain and chemiosmosis. The electron transport chain is a set of proteins found in the inner mitochondrial membrane in eukaryotic cells. Its primary function is to establish a proton gradient that can be used during chemiosmosis to produce ATP and generate electron carriers, such as NAD+ and FAD, that are used in glycolysis and the citric acid cycle.
The ETC is comprised of...
The ETC is comprised of...
112.6K
Amino acids
105.7K
Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible for...
105.7K
Nucleic acids
190.2K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
190.2K
Nucleic Acids
50.6K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
50.6K
The Citric Acid Cycle
162.4K
The citric acid cycle, also known as the Krebs cycle or TCA cycle, consists of several energy-generating reactions that yield one ATP molecule, three NADH molecules, one FADH2 molecule, and two CO2 molecules.
162.4K


