使用半剂量加多皮克莱诺的内淋巴体水的前性MR评估
Rafail Christodoulou1, Nancy Fischbein2, Nikolas Blevins1
1From the Department of Radiology (R.C., N.F., S.M., N.P.), Department of Otolaryngology - Head & Neck Surgery (N.B., L.D.L., F.F.), Stanford University School of Medicine; Department of Radiology (S.M.), VA Palo Alto Healthcare System.
AJNR. American journal of neuroradiology
|February 6, 2026
概括
加多皮克伦醇是一种新的基于加多的对比剂,在内耳成像中有效检测内淋巴水 (EH). 这种药物可以降低剂量,同时保持Ménière疾病评估的诊断准确性.
科学领域:
- 神经辐射学神经辐射学
- 耳鼻科 耳鼻科 耳鼻科 耳鼻科
- 医疗成像医学成像
背景情况:
- 加多皮克伦醇是一种新的基于加多的宏环对比剂 (GBCA),具有高的T1放松性和动力稳定性.
- 它是为了降低加多的剂量和最大限度地降低长期保留风险而开发的.
- 它用于通过延迟内耳成像来评估内淋巴水 (EH) 的实用性仍然未被探索.
研究的目的:
- 评估加多皮克伦醇在延迟对比增强内耳成像中检测内淋巴水 (EH) 的疗效.
- 评估低剂量加多皮克伦醇 (0.05 mmol/kg) 是否可以达到与其他GBCA标准剂量相比的诊断图像质量.
- 确定gadopiclenol用于诊断Ménière病的可靠性和图像质量指标 (SNR,CNR).
主要方法:
- 预期招募26名患有Ménière病标准的患者.
- 延迟 (4小时) 与对比度增强的3T内耳成像使用半剂量gadopiclenol (0.05 mmol/kg).
- 信号与噪声比率 (SNR) 和对比与噪声比率 (CNR) 的定量分析;两个神经放射学家对EH,血液迷宫屏障 (BLB) 透性和囊-囊区分进行了定性评估.
主要成果:
- 对51只耳朵的分析显示,半剂量加多皮克伦醇 (0.05毫摩尔/千克) 和标准剂量加多酸二甲 (0.1毫摩尔/千克) 之间的SNR和CNR可比,没有统计意义 (P>0.05).
- 获得了优秀的观察者间协议 (κ > 0.80),以评分EH.
- 在0.05mmol/kg的加多皮克伦醇证明了可靠检测临床一致的EH.
结论:
- 延迟3D-FLAIR内耳成像用0.05 mmol/kg的gadopiclenol是一种可靠的方法来检测EH.
- 图像质量,从数量和质量上评估,可以与标准剂量的gadobenate dimeglumine相提并论.
- 这种方法支持降低GBCA剂量,用于评估Ménière病和EH.
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