在移植中发生的神经侵入性西尼罗病毒感染:三起病例报告
Alba Temprado Collado1, Marta Suñer Poblet2, Alejandro Suárez Benjumea2
1Department of Nephrology, Hospital de Llerena-Zafra, Badajoz, Spain.
Transplantation proceedings
|February 6, 2026
概括
西尼罗河病毒 (WNV) 对西班牙的移植接受者构成重大威胁,导致严重的神经侵入性疾病. 早期诊断和降低免疫抑制对于在免疫受损患者中管理这种新兴的树冠病毒至关重要.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 移植 移植 移植 移植
背景情况:
- 西尼罗河病毒 (WNV) 是欧洲南部的一个新兴的树木病毒.
- 免疫功能低下的个体,特别是移植接受者,面临严重WNV形式的风险增加.
研究的目的:
- 报告西班牙移植患者中神经侵入性WNV感染的病例.
- 分析这些患者的临床,微生物学和结局数据.
主要方法:
- 追溯的病例系列3个脏移植接受者与神经侵入性WNV感染.
- 数据收集包括人口统计,临床表现,诊断,治疗和结果.
主要成果:
- 所有3名患者都出现了神经侵入性疾病 (脑膜炎或急性松性).
- 在某些情况下,通过血清学 (IgM) 和PCR确认了诊断. 管理包括支持性护理,降低免疫抑制和IVIG在一个病人.
- 结果各不相同,包括完全康复,暂时的赤字,不可逆转的损伤和死亡. 移植功能大多是稳定的.
结论:
- 在西班牙,WNV对移植受体构成新兴威胁,患病率,死亡率和神经系统后果高.
- 早期诊断和调整免疫抑制是至关重要的;IVIG的作用需要进一步研究.
- 对于这种高风险人群,需要专门的管理协议.
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