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Updated: Feb 8, 2026

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结核菌调节宿主ATP6V1E1的酸化,以促进细胞内生存

Jianxia Chen1, Fen Tang2, Lianhua Qin3

  • 1Clinical and Translational Research Center, Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Nature communications
|February 6, 2026
PubMed
概括

结核菌 (Mycobacterium tuberculosis,Mtb) 使用 Chp2 蛋白质阻断 lysosomal 酸化,从而阻碍宿主防御. 抑制BMX激酶会破坏这一过程,从而提供一种潜在的治疗策略来对抗Mtb感染.

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