香伪茎,脚和叶子衍生的微晶纤维素作为直接可压缩的辅助物质的物理化学表征
Amanuel Wledesilasse1,2, Nisha Mary Joseph1, Tesfaye Gabriel1
1Department of Pharmaceutics and Industrial Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia.
香植物生物质提供了纤维素和微晶纤维素 (MCC) 的可持续来源. 这项研究成功地从香叶,伪茎和脚中提取和特征MCC,证明了其作为药物辅助剂在药片配方中的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 制药科学 制药科学
背景情况:
- 木材是纤维素的主要来源,但过度开采需要替代来源.
- 香植物生物质为纤维素提取提供了一个可持续且易于获得的替代品.
- 探索用于纤维素生产的非木质生物质对于环境可持续性至关重要.
研究的目的:
- 从Musa paradisiaca L.植物部位 (叶子,伪茎,脚) 中提取和鉴定纤维素和微晶纤维素 (MCC).
- 评估香衍生的MCC作为药物辅助剂在药片配方中的潜力.
- 为了建立一个无提取过程的纤维素.
主要方法:
- 用无工艺提取纤维素,通过酸水解获得MCC.
- 描述涉及富里埃变换红外光谱学 (FTIR),X射线衍射 (XRD),扫描电子显微镜 (SEM) 和热重力测量分析 (TGA).
- 确定了物理化学性质,结晶性,聚合度 (DP) 和产量. 准备了药片配方,并对物理和机械性能进行了评估.
主要成果:
- FTIR证实了非纤维素杂质的去除;SEM显示了微纤维化的纤维素和棒状MCC结构.
- 香衍生的MCC表现出良好的热稳定性,其结晶度指数与Avicel PH-101相当.
- 获得了高度的纤维素 (高达45%) 和MCC (高达87.3%). 药片配方表现出可接受的物理和机械特性.
结论:
- 香植物生物质是生产纤维素和MCC的可行和可持续来源.
- 从香叶,伪茎和脚中提取的MCC显示出作为制药辅助剂的巨大潜力.
- 这项研究支持利用香生物质等农业废物生产有价值的材料,减少对传统来源的依赖.
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