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基于钢笔的技术打印头用于个性化治疗的高精度微剂量
Paola Carou-Senra1, Carlos Rial2,3, Alex Richter2
1Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D FarmaFacultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Drug delivery and translational research
|February 6, 2026
概括
一种新的基于钢笔的技术印刷方法精确地分发微克的药物剂量,用于个性化医疗. 这种具有成本效益的增材制造方法确保了超低剂量药物输送的高精度和稳定性.
科学领域:
- 制药科学 制药科学
- 增材制造 增材制造 增材制造
- 生物医学工程 生物医学工程
背景情况:
- 目前的制药印刷平台仅限于毫克剂量,阻碍了微剂量应用.
- 现有的技术往往涉及热,气动或电输入,导致分子压力.
- 个性化医疗需要精确地提供超低剂量疗法.
研究的目的:
- 开发一种新的液体沉积系统,用于精确的微尺度药品配送.
- 评估该系统是否适合生产超低剂量口腔膜.
- 展示增材制造在个性化医学中的潜力.
主要方法:
- 一个经过修改的技术笔被集成到药品打印机中,用于重力驱动的液体沉积.
- 德斯莫普拉辛被用作一种模型化合物,用于制造口腔膜,剂量范围为33-134μg.
- 定制软件控制的过程参数,以实现可重复性和自动化工作流程.
主要成果:
- 该系统实现了~100%的剂量准确性,与沉积层的数量有很强的相关性.
- 制作的口腔膜显示了快速分解和药物立即释放.
- 在一个月的稳定性测试中,没有观察到药物的降解.
结论:
- 基于技术笔的打印头是低剂量药品的精确,经济高效的增材制造解决方案.
- 该系统可以使用最小的配方体积 (1毫升238片) 实现高效的生产.
- 这项技术对个性化医疗具有重大潜力,包括生物制剂的输送.
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